ArticleInfection and immunity1996
Trypanosome variant surface glycoproteins are recognized by self-reactive antibodies in uninfected hosts.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.PLoS neglected tropical diseases · 2021Article
- Serological tests for gambiense human African trypanosomiasis detect antibodies in cattle.Parasites & vectors · 2017Article
- The molecular arms race between African trypanosomes and humans.Nature reviews. Microbiology · 2014Review
- Identification of mimotopes with diagnostic potential for Trypanosoma brucei gambiense variant surface glycoproteins using human antibody fractions.PLoS neglected tropical diseases · 2012Article
- CpG oligodeoxynucleotide treatment enhances innate resistance and acquired immunity to African trypanosomes.Infection and immunity · 2007Article
- posttranslational modification of recombinant Plasmodium falciparum apical membrane antigen 1: impact on functional immune responses to a malaria vaccine candidate.Infection and immunity · 2005Article
- Control of experimental Trypanosoma brucei infections occurs independently of lymphotoxin-alpha induction.Infection and immunity · 2002Article
- Comparative analysis of antibody responses against HSP60, invariant surface glycoprotein 70, and variant surface glycoprotein reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma brucei.Infection and immunity · 2000Article
- Interleukin-4-dependent immunoglobulin G1 isotype switch in the presence of a polarized antigen-specific Th1-cell response to the trypanosome variant surface glycoprotein.Infection and immunity · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The variant surface glycoproteins (VSGs) of African trypanosomes form a dense surface coat on the bloodstream parasites. VSGs are immunodominant antigens that stimulate a rapid antibody response in trypanosome-infected individuals. In the present study, we examined VSG-specific antibodies present not only in sera from infected individuals but also in sera from individuals that had never been exposed to trypanosomes. Native antibodies against different VSGs were detected in sera from uninfected mice, bovines, and humans; the antibodies were revealed to be exclusively directed against variable determinants of the antigens. Further experimentation demonstrated that such native antibodies immunoreact with cellular components of mice and thus are most likely produced by the self-reactive B-cell compartment of the murine immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.