ArticleThe EMBO journal1996
The initiator protein E1 binds to the bovine papillomavirus origin of replication as a trimeric ring-like structure.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2.PLoS pathogens · 2016Article
- A conserved regulatory module at the C terminus of the papillomavirus E1 helicase domain controls E1 helicase assembly.Journal of virology · 2015Article
- The E1 proteins.Virology · 2013Review
- Modeling of the SV40 DNA Replication Machine.Genes · 2012Article
- Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle.Virology · 2009Article
- A DNA-binding activity in BPV initiator protein E1 required for melting duplex ori DNA but not processive helicase activity initiated on partially single-stranded DNA.Nucleic acids research · 2008Article
- Papillomavirus E1 protein binds to and stimulates human topoisomerase I.Journal of virology · 2006Article
- Nonspecific double-stranded DNA binding activity of simian virus 40 large T antigen is involved in melting and unwinding of the origin.Journal of virology · 2003Article
- E1 initiator DNA binding specificity is unmasked by selective inhibition of non-specific DNA binding.The EMBO journal · 2003Article
- Sequential and ordered assembly of E1 initiator complexes on the papillomavirus origin of DNA replication generates progressive structural changes related to melting.Molecular and cellular biology · 2002Article
- Papillomavirus E1 proteins: form, function, and features.Virus genes · 2002Review
- The E1 initiator recognizes multiple overlapping sites in the papillomavirus origin of DNA replication.Journal of virology · 2001Article
- Identification of domains of the human papillomavirus type 11 E1 helicase involved in oligomerization and binding to the viral origin.Journal of virology · 2000Article
- The differentiation-specific factor CDP/Cut represses transcription and replication of human papillomaviruses through a conserved silencing element.Journal of virology · 2000Article
- Article
- Review
- Role of the ATP-binding domain of the human papillomavirus type 11 E1 helicase in E2-dependent binding to the origin.Journal of virology · 1999Article
- Effect of bovine papillomavirus E2 protein-specific monoclonal antibodies on papillomavirus DNA replication.Journal of virology · 1999Article
- Recruitment and loading of the E1 initiator protein: an ATP-dependent process catalysed by a transcription factor.The EMBO journal · 1998Article
- A fifteen-amino-acid peptide inhibits human papillomavirus E1-E2 interaction and human papillomavirus DNA replication in vitro.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The replication initiator protein E1 binds to the origin of replication of bovine papillomavirus in several forms. E1 can bind to its recognition sequence as a monomer together with the viral transcription factor E2, or as a trimeric E1 complex. The trimerization of E1 is mediated by the sequence-specific binding of E1 to DNA, and results in an E1 complex that is linked topologically to the DNA because the three molecules of E1 form a ring-like structure that encircles the DNA. These results demonstrate that E1 utilizes unusual mechanisms for sequence-specific binding to DNA and for the generation of a structure that encircles the DNA. We believe that these forms of E1 bound to the origin of replication represent intermediates in a transition in the function of E1, from a sequence-specific origin of replication recognition protein to a form of E1 that is competent for the initiation of viral DNA replication.
Indexed as
Identifiers
8890182PMC452248W1872680925What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.