ArticleThe EMBO journal1996
E47 activates the Ig-heavy chain and TdT loci in non-B cells.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 104 citations in OpenAlex.
- Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4.Nucleic acids research · 2024Article
- The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia.Annals of hematology · 2024Review
- E proteins control the development of NKγδT cells through their invariant T cell receptor.Nature communications · 2024Article
- Helix-Loop-Helix Proteins in Adaptive Immune Development.Frontiers in immunology · 2022Review
- E proteins in lymphocyte development and lymphoid diseases.Current topics in developmental biology · 2014Review
- YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus.The EMBO journal · 2013Article
- Id1 has a physiological role in regulating early B lymphopoiesis.Cellular & molecular immunology · 2011Article
- Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells.PloS one · 2011Article
- Immunoglobulin expression in non-lymphoid lineage and neoplastic cells.The American journal of pathology · 2009Review
- Article
- Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.Nature immunology · 2008Article
- Transcriptional regulation of early B cell development.Immunologic research · 2008Review
- Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation.Cancer letters · 2007Review
- Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer.Molecular cancer · 2007Article
- E2A promotes the survival of precursor and mature B lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Regulation of immunoglobulin gene transcription in a teleost fish: identification, expression and functional properties of E2A in the channel catfish.Immunogenetics · 2005Article
- Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.The Journal of biological chemistry · 2004Article
- Identification of cyclin D3 as a direct target of E2A using DamID.Molecular and cellular biology · 2004Article
- Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A.The Journal of experimental medicine · 2004Article
- Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The E2A proteins, E12 and E47, are basic helix-loop-helix (bHLH) proteins essential for the B-cell lineage. Initially identified as immunoglobulin enhancer-binding proteins, they have also been shown to activate immunoglobulin enhancer-based reporters in transient transfection assays. Here, we examine the relationship between E2A DNA binding activity and activation of the endogenous, chromosomal immunoglobulin heavy chain (IgH) locus. Using sterile I(mu) transcription as an indicator of IgH enhancer activity, we see a direct correlation between E2A DNA binding activity and I(mu) transcription in stable BxT hybrids. We also observe a 1000-fold stimulation of endogenous I(mu) transcription in fibroblasts that express high levels of E47 and less stimulation in cells that express E12. By contrast, none of the other IgH enhancer-binding proteins tested (E2-2, Pu.1, Oct-2, OCA-B, TFE3 and USF) were able to activate I(mu) transcription. E47 overexpression also resulted in transcriptional activation of the endogenous gene encoding TdT, indicating that it, too, is a target of E2A proteins early in the B-cell lineage. Our results indicate that E2A proteins have the distinctive property of activating silent, chromatin-embedded B-cell-specific genes, underscoring their crucial role in B-cell development.
Indexed as
Identifiers
8890174PMC452239W1576142340What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.