ArticleThe EMBO journal1996
A molecular code dictates sequence-specific DNA recognition by homeodomains.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 93 citations in OpenAlex.
- HOXA9 Regulome and Pharmacological Interventions in Leukemia.Advances in experimental medicine and biology · 2024Review
- NK2 homeobox gene cluster: Functions and roles in human diseases.Genes & diseases · 2023Review
- Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires.Journal of molecular evolution · 2021Article
- Phylogenetic and mutational analyses of human LEUTX, a homeobox gene implicated in embryogenesis.Scientific reports · 2018Article
- Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development.eLife · 2018Article
- A LINE-1 insertion in DLX6 is responsible for cleft palate and mandibular abnormalities in a canine model of Pierre Robin sequence.PLoS genetics · 2014Article
- Binding polymorphism in the DNA bound state of the Pdx1 homeodomain.PLoS computational biology · 2013Article
- Exploring the DNA-recognition potential of homeodomains.Genome research · 2012Article
- Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1).The Journal of biological chemistry · 2012Article
- Recognition models to predict DNA-binding specificities of homeodomain proteins.Bioinformatics (Oxford, England) · 2012Article
- Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression.Journal of neuroendocrinology · 2012Article
- Article
- Using the recognition code to swap homeodomain target specificity in cell culture.Molecular biology reports · 2011Article
- Thyroid transcription factor-1 regulates feeding behavior via melanocortin pathway in the hypothalamus.Diabetes · 2011Article
- TTF-1 action on the transcriptional regulation of cyclooxygenase-2 gene in the rat brain.PloS one · 2011Article
- Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor.Journal of molecular biology · 2009Article
- Predicting the binding preference of transcription factors to individual DNA k-mers.Bioinformatics (Oxford, England) · 2009Article
- Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors.Bioinformatics (Oxford, England) · 2008Article
- Multiple intrinsically disordered sequences alter DNA binding by the homeodomain of the Drosophila hox protein ultrabithorax.The Journal of biological chemistry · 2008Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most homeodomains bind to DNA sequences containing the motif 5'-TAAT-3'. The homeodomain of thyroid transcription factor 1 (TTF-1HD) binds to sequences containing a 5'-CAAG-3' core motif, delineating a new mechanism for differential DNA recognition by homeodomains. We investigated the molecular basis of the DNA binding specificity of TTF-1HD by both structural and functional approaches. As already suggested by the three-dimensional structure of TTF-1HD, the DNA binding specificities of the TTF-1, Antennapedia and Engrailed homeodomains, either wild-type or mutants, indicated that the amino acid residue in position 54 is involved in the recognition of the nucleotide at the 3' end of the core motif 5'-NAAN-3'. The nucleotide at the 5' position of this core sequence is recognized by the amino acids located in position 6, 7 and 8 of the TTF-1 and Antennapedia homeodomains. These data, together with previous suggestions on the role of amino acids in position 50, indicate that the DNA binding specificity of homeodomains can be determined by a combinatorial molecular code. We also show that some specific combinations of the key amino acid residues involved in DNA recognition do not follow a simple, additive rule.
Indexed as
Identifiers
8890172PMC452237W169392055What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.