ArticleThe EMBO journal1996
The fork head product directly specifies the tissue-specific hormone responsiveness of the Drosophila Sgs-4 gene.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- The Drosophila larval salivary gland, a simple and elegant model system to understand secretory organ development and function.Current opinion in insect science · 2026Review
- Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene.Current biology : CB · 2024Article
- Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Anatomy and evolution of a DNA replication origin.Chromosoma · 2021Article
- Evolution of salivary glue genes in Drosophila species.BMC evolutionary biology · 2019Article
- Article
- A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila.Nucleic acids research · 2014Article
- Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function.Development (Cambridge, England) · 2012Article
- The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- The molecular basis of organ formation: insights from the C. elegans foregut.Annual review of cell and developmental biology · 2009Review
- Genetic control of programmed cell death during animal development.Annual review of genetics · 2009Review
- A novel ecdysone receptor mediates steroid-regulated developmental events during the mid-third instar of Drosophila.PLoS genetics · 2008Article
- Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Gene expression patterns in primary neuronal clusters of the Drosophila embryonic brain.Gene expression patterns : GEP · 2007Article
- Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death.The Journal of cell biology · 2007Article
- Article
- Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues.The Journal of cell biology · 2004Article
- Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we describe the identification of four binding sites of secretion enhancer binding protein 2 (SEBP2) in the regulatory region of the Drosophila salivary gland secretion protein gene 4 (Sgs-4) and show that despite these sites' correspondence with previously described Broad-Complex protein binding sites, SEBP2 is a Broad-Complex-independent factor encoded by the region-specific homeotic gene fork head (fkh). Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone. We demonstrate that these binding sites are relevant to the transcriptional activation of Sgs-4 and show that Fork head also binds to the Sgs-4 ecdysone response unit in vivo. Aside from being involved in the control of decisions during embryonic development, fkh thus participates directly in the control of specialized functions of differentiated cells at later stages of development.
Indexed as
Identifiers
8890156PMC452219What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.