ArticleGenetics1996
Sequence analysis of eukaryotic developmental proteins: ancient and novel domains.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Molecular Prediction and Correlation of the Structure and Function of Universal Stress Protein A (UspA) from Salmonella Typhimurium.Biochemical genetics · 2025Article
- Characterization of the MADS-Box Gene Family inGenes · 2022Article
- Identification and expression profiling of selected MADS-box family genes in Dendrobium officinale.Genetica · 2019Article
- Overexpression of an Orchid (Dendrobium nobile) SOC1/TM3-Like Ortholog, DnAGL19, in Arabidopsis Regulates HOS1-FT Expression.Frontiers in plant science · 2016Article
- Transcriptional, posttranscriptional, and posttranslational regulation of SHOOT MERISTEMLESS gene expression in Arabidopsis determines gene function in the shoot apex.Plant physiology · 2015Article
- Phylogenetic analysis of STK gene family and Usp domain in maize.Molecular biology reports · 2014Article
- Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects.Genome research · 2005Article
- A novel antimicrobial protein isolated from potato (Solanum tuberosum) shares homology with an acid phosphatase.The Biochemical journal · 2003Article
- The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers.Genome biology · 2003Article
- Functional analysis of the conserved domains of a rice KNOX homeodomain protein, OSH15.The Plant cell · 2001Article
- Identification and characterization of mycobacterial proteins differentially expressed under standing and shaking culture conditions, including Rv2623 from a novel class of putative ATP-binding proteins.Infection and immunity · 2001Article
- An ancestral MADS-box gene duplication occurred before the divergence of plants and animals.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A short history of MADS-box genes in plants.Plant molecular biology · 2000Review
- Homologues of 26S proteasome subunits are regulators of transcription and translation.Protein science : a publication of the Protein Society · 1998Article
- Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most of the genes involved in the development of multicellular eukaryotes encode large, multidomain proteins. To decipher the major trends in the evolution of these proteins and make functional predictions for uncharacterized domains, we applied a strategy of sequence database search that includes construction of specialized data sets and iterative subsequence masking. This computational approach allowed us to detect previously unnoticed but potentially important sequence similarities. Developmental gene products are enriched in predicted nonglobular regions as compared to unbiased sets of eukaryotic and bacterial proteins. Developmental genes that act intracellularly, primarily at the level of transcription regulation, typically code for proteins containing highly conserved DNA-binding domains, most of which appear to have evolved before the radiation of bacteria and eukaryotes. We identified bacterial homologues, namely a protein family that includes the Escherichia coli universal stress protein UspA, for the MADS-box transcription regulators previously described only in eukaryotes. We also show that the FUS6 family of eukaryotic proteins contains a putative DNA-binding domain related to bacterial helix-turn-helix transcription regulators. Developmental proteins that act extracellularly are less conserved and often do not have bacterial homologues. Nevertheless, several provocative similarities between different groups of such proteins were detected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.