ArticleGenetics1996
Somatic reversion of chromosomal position effects in Drosophila melanogaster.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Live analysis of position-effect variegation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Monitoring of switches in heterochromatin-induced silencing shows incomplete establishment and developmental instabilities.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transgenerational inheritance of diet-induced genome rearrangements in Drosophila.PLoS genetics · 2015Article
- Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells.Genes & development · 2014Article
- Highly specific and efficient CRISPR/Cas9-catalyzed homology-directed repair in Drosophila.Genetics · 2014Article
- Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Cold Spring Harbor perspectives in biology · 2013Review
- Article
- Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss.PLoS genetics · 2011Article
- Perturbation analysis of heterochromatin-mediated gene silencing and somatic inheritance.PLoS genetics · 2010Article
- The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.Cell stem cell · 2009Article
- The XNP remodeler targets dynamic chromatin in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Quantification of Cre-mediated recombination by a novel strategy reveals a stable extra-chromosomal deletion-circle in mice.BMC biotechnology · 2008Article
- Article
- Idefix insulator activity can be modulated by nearby regulatory elements.Nucleic acids research · 2007Article
- The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability.Genetics · 2006Article
- Rare instances of Cre-mediated deletion product maintained in transgenic wheat.Plant molecular biology · 2003Article
- A self-excising Cre recombinase allows efficient recombination of multiple ectopic heterospecific lox sites in transgenic tobacco.Transgenic research · 2003Article
- Promoter competition as a mechanism of transcriptional interference mediated by retrotransposons.The EMBO journal · 2002Article
- Coupling of enhancer and insulator properties identified in two retrotransposons modulates their mutagenic impact on nearby genes.Molecular and cellular biology · 2002Article
- Polycomb group repression reduces DNA accessibility.Molecular and cellular biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A transgene was inserted at several different chromosomal sites in Drosophila melanogaster, where its expression was subject to genomic position effects. Quantitative position effects and variegated and constant patterned position effects were observed. We investigated the status of the affected gene in the somatic cells where it normally functions. The FLP site-specific recombinase was used to remove the gene from the chromosome and its expression was then evaluated. We show that the FLP recombinase functions in cells that have finished their developmental program of mitoses. When FLP acts on directly repeated copies of its target site (FRT), the DNA flanked by those FRTs is excised from the chromosome as a closed circle. The extrachromosomal circle is maintained in nondividing cells, and a gene located on such a circle can be expressed. We then demonstrate that a gene subject to either variegated or constant position effect can be relieved of that effect by excision of the gene from the chromosome in cells where it would otherwise be inactive. We also observed a strong inhibition of FLP-mediated recombination for target sites located near centric heterochromatin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.