ArticleGenetics1996
Multi-locus selection and the structure of variation at the white gene of Drosophila melanogaster.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The classical hitchhiking model with continuous mutational pressure and purifying selection.Ecology and evolution · 2021Article
- Polygenic Adaptation in a Population of Finite Size.Entropy (Basel, Switzerland) · 2020Review
- Selective Sweeps.Genetics · 2019Review
- Signatures of natural selection in abiotic stress-responsive genes ofRoyal Society open science · 2018Article
- A selective sweep across species boundaries in Drosophila.Molecular biology and evolution · 2013Article
- Sequence evolution and expression regulation of stress-responsive genes in natural populations of wild tomato.PloS one · 2013Article
- Article
- Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.Genetics · 2012Article
- Searching for footprints of positive selection in whole-genome SNP data from nonequilibrium populations.Genetics · 2010Article
- Patterns of molecular evolution associated with two selective sweeps in the Tb1-Dwarf8 region in maize.Genetics · 2008Article
- Hitchhiking both ways: effect of two interfering selective sweeps on linked neutral variation.Genetics · 2008Article
- Article
- The speed of adaptation in large asexual populations.Genetics · 2004Article
- Article
- Functional divergence in tandemly duplicated Arabidopsis thaliana trypsin inhibitor genes.Genetics · 2004Article
- Article
- Article
- Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection.Journal of molecular evolution · 2003Article
- Applications of selective neutrality tests to molecular ecology.Molecular ecology · 2002Review
- Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans.Genetics · 2001Article
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2 authors.
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Abstract
We surveyed sequence variation and divergence for the entire 5972-bp transcriptional unit of the white gene in 15 lines of Drosophila melanogaster and one line of D. simulans. We found a very high degree of haplotypic structuring for the polymorphisms in the 3' half of the gene, as opposed to the polymorphisms in the 5' half. To determine the evolutionary mechanisms responsible for this pattern we sequenced a 1612-bp segment of the white gene from an additional 33 lines of D. melanogaster from a European and a North American population. This 1612-bp segment encompasses an 834-bp region of the white gene in which the polymorphisms form high frequency haplotypes that cannot be explained by a neutral equilibrium model of molecular evolution. The small number of recombinants in the 834-bp region suggests epistatic selection as the cause of the haplotypic structuring, while an investigation of nucleotide diversity supports a directional selection hypothesis. A multi-locus selection model that combines features from both hypotheses and takes the recent history of D. melanogaster into account may be the best explanation for these data.
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