ArticleGenetics1996
Escape from het-6 incompatibility in Neurospora crassa partial diploids involves preferential deletion within the ectopic segment.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Trans-species activity of a nonself recognition domain.BMC microbiology · 2013Article
- SO, a protein involved in hyphal fusion in Neurospora crassa, localizes to septal plugs.Eukaryotic cell · 2007Article
- Genetic basis of the ovc phenotype of Neurospora: identification and analysis of a 77 kb deletion.Current genetics · 2007Article
- A nonself recognition gene complex in Neurospora crassa.Genetics · 2006Article
- Article
- Chromosome rearrangements in isolates that escape from het-c heterokaryon incompatibility in Neurospora crassa.Current genetics · 2004Article
- Genetic analysis of wild-isolated Neurospora crassa strains identified as dominant suppressors of repeat-induced point mutation.Genetics · 2003Article
- The ham-2 locus, encoding a putative transmembrane protein, is required for hyphal fusion in Neurospora crassa.Genetics · 2002Article
- Identification of specificity determinants and generation of alleles with novel specificity at the het-c heterokaryon incompatibility locus of Neurospora crassa.Molecular and cellular biology · 2001Article
- Molecular genetics of heterokaryon incompatibility in filamentous ascomycetes.Microbiology and molecular biology reviews : MMBR · 2000Review
- Mutational analysis of the [Het-s] prion analog of Podospora anserina. A short N-terminal peptide allows prion propagation.Genetics · 1999Article
- Characterization of mat A-2, mat A-3 and deltamatA mating-type mutants of Neurospora crassa.Genetics · 1998Article
- Allelic specificity at the het-c heterokaryon incompatibility locus of Neurospora crassa is determined by a highly variable domain.Genetics · 1997Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Self-incompatible het-6OR/het-6PA partial diploids of Neurospora crassa were selected from a cross involving the translocation strain, T(IIL-->IIIR)AR18, and a normal sequence strain. About 25% of the partial diploids exhibited a marked increase in growth rate after 2 weeks, indicating that "escape" from het-6 incompatibility had occurred. Near isogenic tester strains with different alleles (het-6OR and het-6PA) were constructed and used to determine that 80 of 96 escape strains tested were het-6PA, retaining the het-6 allele found in the normal-sequence LGII position; 16 were het-6OR, retaining the allele in the translocated position. Restriction fragment length polymorphisms in 45 escape strains were examined with probes made from cosmids that spanned the translocated region. Along with electrophoretic analysis of chromosomes from three escape strains, RFLPs showed that escape is associated with deletion of part of one or the other of the duplicated DNA segments. Deletions ranged in size from approximately 70 kbp up to putatively the entire 270-kbp translocated region but always included a 35-kbp region wherein we hypothesize het-6 is located. The deletion spectrum at het-6 thus resembles other cases where mitotic deletions occur such as of tumor suppressor genes and of the hprt gene (coding for hypoxanthine-guanine phosphoribosyl-transferase) in humans.
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