ArticleGenetics1996
SEC3 mutations are synthetically lethal with profilin mutations and cause defects in diploid-specific bud-site selection.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Exocyst components promote an incompatible interaction between Glycine max (soybean) and Heterodera glycines (the soybean cyst nematode).Scientific reports · 2020Article
- Integrative structure and function of the yeast exocyst complex.Protein science : a publication of the Protein Society · 2020Article
- Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex.Nature structural & molecular biology · 2016Article
- Cell polarization and cytokinesis in budding yeast.Genetics · 2012Review
- Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization.Development (Cambridge, England) · 2010Article
- Sec6p anchors the assembled exocyst complex at sites of secretion.Molecular biology of the cell · 2009Article
- Swf1p, a member of the DHHC-CRD family of palmitoyltransferases, regulates the actin cytoskeleton and polarized secretion independently of its DHHC motif.Molecular biology of the cell · 2008Article
- Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum.Molecular biology of the cell · 2003Article
- Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast.The Journal of cell biology · 2003Article
- Iqg1p links spatial and secretion landmarks to polarity and cytokinesis.The Journal of cell biology · 2002Article
- Generation of an isogenic collection of yeast actin mutants and identification of three interrelated phenotypes.Genetics · 2001Article
- Article
- Polarized growth controls cell shape and bipolar bud site selection in Saccharomyces cerevisiae.Molecular and cellular biology · 2000Article
- The secretory pathway mediates localization of the cell polarity regulator Aip3p/Bud6p.Molecular biology of the cell · 2000Article
- The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting.The Journal of cell biology · 1999Article
- Identification of a suppressor of the Dictyostelium profilin-minus phenotype as a CD36/LIMP-II homologue.The Journal of cell biology · 1999Article
- GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro.Molecular biology of the cell · 1999Article
- SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Tethering molecules in membrane traffic.Protoplasma · 1999Article
- Spatial regulation of exocytosis: lessons from yeast.The Journal of cell biology · 1998Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Replacement of the wild-type yeast profilin gene (PFY1) with a mutated form (pfy1-111) that has codon 72 changed to encode glutamate rather than arginine results in defects similar to, but less severe than, those that result from complete deletion of the profilin gene. We have used a colony color-sectoring assay to identify mutations that cause pfy1-111, but not wild-type, cells to be inviable. These profilin synthetic lethal (psl) mutations result in various degrees of abnormal growth, morphology, and temperature sensitivity in PFY1 cells. We have examined psl1 strains in the most detail. Interestingly, these strains display a diploid-specific defect in bud-site selection; haploid strains bud normally, while homozygous diploid strains show a dramatic increase in random budding. We discovered that PSL1 is the late secretory gene, SEC3, and have found that mutations in several other late secretory genes are also synthetically lethal with pfy1-111. Our results are likely to reflect an interdependence between the actin cytoskeleton and secretory processes in directing cell polarity and growth. Moreover, they indicate that the secretory pathway is especially crucial for maintaining budding polarity in diploids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.