ArticleBiophysical journal1996
Quantal release, incremental detection, and long-period Ca2+ oscillations in a model based on regulatory Ca2+-binding sites along the permeation pathway.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- A mathematical model of calcium dynamics in HSY cells.PLoS computational biology · 2017Article
- Actin-based confinement of calcium responses during Shigella invasion.Nature communications · 2013Article
- Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating.The Journal of general physiology · 2012Article
- Calcium oscillations.Cold Spring Harbor perspectives in biology · 2011Review
- Unitary Ca(2+) current through recombinant type 3 InsP(3) receptor channels under physiological ionic conditions.The Journal of general physiology · 2010Article
- Spatiotemporal organization of Ca dynamics: a modeling-based approach.HFSP journal · 2010Article
- Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels.The Journal of general physiology · 2007Article
- A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores.The Biochemical journal · 2003Article
- On the role of stochastic channel behavior in intracellular Ca2+ dynamics.Biophysical journal · 2003Article
- From calcium blips to calcium puffs: theoretical analysis of the requirements for interchannel communication.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Agonist-dependent phosphorylation of the inositol 1,4,5-trisphosphate receptor: A possible mechanism for agonist-specific calcium oscillations in pancreatic acinar cells.The Journal of general physiology · 1999Article
- Differential modulation of the phases of a Ca2+ spike by the store Ca2+-ATPase in human umbilical vein endothelial cells.The Journal of physiology · 1998Article
- A general computational framework for modeling cellular structure and function.Biophysical journal · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantal release, incremental detection, and oscillations are three types of Ca2+ responses that can be obtained in different conditions, after stimulation of the intracellular Ca2+ stores by submaximum concentrations of inositol 1,4,5-triphosphate (InsP3). All three phenomena are thought to occur through the regulatory properties of the InsP3 receptor/Ca2+ channel. In the present study, we perform further analysis of the model (Swillens et al., 1994, Proc. Natl. Acad. Sci. USA. 91:10074-10078) previously proposed for transient InsP3-induced Ca2+ release, based on the bell-shaped dependence of the InsP3 receptor activity on the Ca2+ level and on the existence of an intermediate Ca2+ domain located around the mouth of the channel. We show that Ca2+ oscillations also arise in the latter model. Conditions for the occurrence of the various behaviors are investigated. Numerical simulations also show that the existence of an intermediate Ca2+ domain can markedly increase the period of oscillations. Periods on the order of 1 min can indeed be accounted for by the model when one assigns realistic values to the kinetic constants of the InsP3 receptor, which, in the absence of a domain, lead to oscillations with periods of a few seconds. Finally, theoretical support in favor of a positive cooperativity in the regulation of the InsP3 receptor by Ca2+ is presented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.