ArticleDigestive diseases and sciences1996
Impact of gastrointestinal dysfunction on survival after liver transplantation for familial amyloidotic polyneuropathy.
Article in Digestive diseases and sciences, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- The impact of inotersen on Neuropathy Impairment Score in patients with hereditary transthyretin amyloidosis with polyneuropathy.BMC neurology · 2023Trial
- Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis.Journal of neurology · 2020Trial
- Fecal calprotectin levels are elevated in transthyretin amyloidosis patients with gastrointestinal manifestations.Medicine · 2020Observational
- Diagnosis and treatment of gastrointestinal dysfunction in hereditary TTR amyloidosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Outcome of gastric emptying and gastrointestinal symptoms after liver transplantation for hereditary transthyretin amyloidosis.BMC gastroenterology · 2015Article
- THAOS: gastrointestinal manifestations of transthyretin amyloidosis - common complications of a rare disease.Orphanet journal of rare diseases · 2014Article
- Loss of gastric interstitial cells of Cajal in patients with hereditary transthyretin amyloidosis.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · 2013Article
- Gastric emptying in hereditary transthyretin amyloidosis: the impact of autonomic neuropathy.Neurogastroenterology and motility · 2012Article
- Transthyretin-related familial amyloidotic polyneuropathy-Progress in Kumamoto, Japan (1967-2010)-.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
- Systemic amyloidosis and the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2009Review
- Liver transplantation and new therapeutic approaches for familial amyloidotic polyneuropathy (FAP).Medical molecular morphology · 2005Review
- Targeted conversion of the transthyretin gene in vitro and in vivo.Gene therapy · 2004Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver transplantation is the only effective treatment of familial amyloidotic polyneuropathy type I (FAP). The aim of the present investigation was to identify factors at the time of submission for transplantation that had impact on survival, with special reference to gastrointestinal disturbances. All 28 liver-transplanted FAP patients evaluated at Umeå University Hospital were included in the study. A modified body mass index was used to assess nutritional status. Intestinal examinations were performed to diagnose bile acid malabsorption, gastric retention, and bacterial contamination of the small bowel. A significantly improved survival rate was found for patients in a good nutritional state (P = 0.002). Peripheral neurological symptoms were unrelated to survival, whereas increased mortality was found for patients with bile acid malabsorption (P < 0.05). Bacterial contamination and gastric retention were common complications of the disease. In conclusion, malabsorption and malnutrition have a profound impact on the outcome of liver transplantation for familial amyloidotic polyneuropathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.