ArticleThe Journal of physiology1996
Inwardly rectifying currents in hair cells and supporting cells in the goldfish sacculus.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 36 citations in OpenAlex.
- In vivo physiological recording from the lateral line of juvenile zebrafish.The Journal of physiology · 2016Article
- In vivo and in vitro biophysical properties of hair cells from the lateral line and inner ear of developing and adult zebrafish.The Journal of physiology · 2014Article
- HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.The Journal of biological chemistry · 2012Article
- The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear.Journal of neurophysiology · 2012Article
- HCN channels expressed in the inner ear are necessary for normal balance function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Structural and functional effects of acoustic exposure in goldfish: evidence for tonotopy in the teleost saccule.BMC neuroscience · 2011Article
- Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- An adenylyl cyclase signaling pathway predicts direct dopaminergic input to vestibular hair cells.Neuroscience · 2010Article
- Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3.The Journal of biological chemistry · 2009Article
- Developmental acquisition of voltage-dependent conductances and sensory signaling in hair cells of the embryonic mouse inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Differences between the negatively activating potassium conductances of Mammalian cochlear and vestibular hair cells.Journal of the Association for Research in Otolaryngology : JARO · 2004Article
- Role of hyperpolarization-activated currents for the intrinsic dynamics of isolated retinal neurons.Biophysical journal · 2003Article
- Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Postnatal development of type I and type II hair cells in the mouse utricle: acquisition of voltage-gated conductances and differentiated morphology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Activation and two modes of blockade by strontium of Ca2+-activated K+ channels in goldfish saccular hair cells.The Journal of general physiology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Inwardly rectifying ionic currents were studied using patch-clamp recording methods in oscillatory-type and spike-type hair cells and supporting cells dissociated from the goldfish sacculus. These cells had different types of inwardly rectifying currents. The biophysical properties of these currents were investigated. 2. A unique potassium current (Isc) was the sole ionic current recognized in supporting cells. Isc was active throughout the membrane potential range between +30 and -170 mV, but showed weak inward rectification and no inactivation. 3. In spike-type hair cells, inwardly rectifying current (Ik1) was selectively permeable to K+ (K+:Na+ permeability ratio, 1:0.0021). Ik1 could underlie the high negative resting potential of these hair cells because it is partially active at this potential. The strong inward rectification of Ik1 contributed to the low negative plateau potential seen in spike-type hair cells. 4. In oscillatory-type hair cells, hyperpolarization-activated potassium-sodium current (Ih), which had properties similar to that in photoreceptor and other neurons, was present instead of inwardly rectifying K+ current. 5. In the cell-attached and inside-out modes with 125 microM external K+ ([K+]o), IK1 channel had a unitary conductance of 27 pS and showed inactivation with increasing hyperpolarization. Putative Ih and Iso single channels had unitary conductances of 7 and 61 pS, respectively, in the cell-attached mode with 125 microM Ko+.
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