ArticleThe Journal of physiology1996
Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 79 citations in OpenAlex.
- The addition of β-Hydroxy β-Methylbutyrate (HMB) to creatine monohydrate supplementation does not improve anthropometric and performance maintenance across a collegiate rugby season.Journal of the International Society of Sports Nutrition · 2020Trial
- Trial
- Relationship between muscle water and glycogen recovery after prolonged exercise in the heat in humans.European journal of applied physiology · 2015Trial
- Nutritional Strategies to Improve Post-exercise Recovery and Subsequent Exercise Performance: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2025Review
- Potential of Creatine in Glucose Management and Diabetes.Nutrients · 2021Review
- Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview.Sports medicine (Auckland, N.Z.) · 2017Review
- Performance Enhancing Diets and the PRISE Protocol to Optimize Athletic Performance.Journal of nutrition and metabolism · 2015Review
- Are we being drowned in hydration advice? Thirsty for more?Extreme physiology & medicine · 2014Review
- Effect of glutamine and maltodextrin acute supplementation on anaerobic power.Asian journal of sports medicine · 2013Article
- Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake.The Journal of physiology · 2013Article
- Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells.The Journal of physiology · 2004Article
- Amino acid transporters: roles in amino acid sensing and signalling in animal cells.The Biochemical journal · 2003Review
- Oral creatine supplementation and skeletal muscle metabolism in physical exercise.Sports medicine (Auckland, N.Z.) · 2002Review
- Thermogenesis induced by intravenous infusion of hypertonic solutions in the rat.The Journal of physiology · 2001Article
- Integrin and cytoskeletal involvement in signalling cell volume changes to glutamine transport in rat skeletal muscle.The Journal of physiology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The hypothesis that cellular hydration state modulates muscle glycogen synthesis was tested by measuring the incorporation of [14C]glucose into glycogen (glycogen synthesis) in primary rat myotubes after experimentally induced volume changes. 2. Glycogen synthesis in myotubes increased (by 75%, P < 0.01) after swelling induced by 60 min exposure to hyposmotic media (170 mosmol kg-1) relative to isosmotic control (300 mosmol kg-1) values, it decreased (by 31%, P < 0.05) after shrinkage induced by 60 min exposure to hyperosmotic (430 mosmol kg-1) media. Myotube 2-deoxy-D-glucose (0.05 mM) uptake was unaffected by changes in external osmolality. 3. Wortmannin (100 nM; 60 min), a phosphatidylinositol 3-kinase inhibitor, decreased basal glycogen synthesis by 28% whereas rapamycin (100 nM; 60 min), which blocks the activation of p70 S6 kinase, had no effect. Both wortmannin (100 nM; 60 min) and rapamycin (100 nM; 60 min) blocked the changes in glycogen synthesis resulting from hypo- and hyperosmotic exposure. 4. Myotube glycogen synthesis is modulated by volume changes independently of changes in glucose uptake. The phenomenon may be physiologically important in promoting glycogen storage during circumstances of myofibrillar swelling, e.g. after feeding or exercise.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.