ArticleMolecular and cellular biology1996
Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 111 citations in OpenAlex.
- Non-canonical roles of apoptotic and DNA double-strand break repair factors in mediating cellular response to ionizing radiation.International journal of radiation biology · 2023Review
- The intercellular communications mediating radiation-induced bystander effects and their relevance to environmental, occupational, and therapeutic exposures.International journal of radiation biology · 2023Review
- Transcriptomes of Wet Skin Biopsies Predict Outcomes after Ionizing Radiation Exposure with Potential Dosimetric Applications in a Mouse Model.Current issues in molecular biology · 2022Article
- Origin of Cancer: An Information, Energy, and Matter Disease.Frontiers in cell and developmental biology · 2016Article
- Karyotypic evolutions of cancer species in rats during the long latent periods after injection of nitrosourea.Molecular cytogenetics · 2014Article
- Article
- What mechanisms/processes underlie radiation-induced genomic instability?Cellular and molecular life sciences : CMLS · 2012Article
- Intrachromosomal changes and genomic instability in site-specific microbeam-irradiated and bystander human-hamster hybrid cells.Radiation research · 2012Article
- Heavy ions, radioprotectors and genomic instability: implications for human space exploration.Radiation and environmental biophysics · 2010Review
- Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies.Leukemia research · 2010Article
- Transgenerational accumulation of radiation damage in small mammals chronically exposed to Chernobyl fallout.Radiation and environmental biophysics · 2006Article
- Ionizing radiation induces delayed hyperrecombination in Mammalian cells.Molecular and cellular biology · 2004Article
- Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation.Oncogene · 2003Review
- Article
- Review
- Role of genetic background in induced instability.Oncogene · 2003Review
- Article
- Radiation-induced mutations in unirradiated DNA.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Illegitimate recombination leading to allelic loss and unbalanced translocation in p53-mutated human lymphoblastoid cells.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Many tumors exhibit extensive chromosomal instability, but karyotypic alterations will be significant in carcinogenesis only by influencing specific oncogenes or tumor suppressor loci within the affected chromosomal segments. In this investigation, the specificity of chromosomal rearrangements attributable to radiation-induced genomic instability is detailed, and a qualitative and quantitative correspondence with mutagenesis is demonstrated. Chromosomal abnormalities preferentially occurred near the site of prior rearrangements, resulting in complex abnormalities, or near the centromere, resulting in deletion or translocation of the entire chromosome arm, but no case of an interstitial chromosomal deletion was observed. Evidence for chromosomal instability in the progeny of irradiated cells also included clonal karyotypic heterogeneity. The persistence of instability was demonstrated for at least 80 generations by elevated mutation rates at the heterozygous, autosomal marker locus tk. Among those TK- mutants that showed a loss of heterozygosity, a statistically significant increase in mutation rate was observed only for those in which the loss of heterozygosity encompasses the telomeric region. This mutational specificity corresponds with the prevalence of terminal deletions, additions, and translocations, and the absence of interstitial deletions, in karyotypic analysis. Surprisingly, the elevated rate of TK- mutations is also partially attributable to intragenic base substitutions and small deletions, and DNA sequence analysis of some of these mutations is presented. Complex chromosomal abnormalities appear to be the most significant indicators of a high rate of persistent genetic instability which correlates with increased rates of both intragenic and chromosomal-scale mutations at tk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.