ArticleMolecular and cellular biology1996
RIP-140 interacts with multiple nuclear receptors by means of two distinct sites.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
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- The prognostic marker NRIP1 is associated with tumor progression and immune infiltration in acute myeloid leukemia.Acta biochimica et biophysica Sinica · 2025Article
- Multifaceted Transcriptional Network of Estrogen-Related Receptor Alpha in Health and Disease.International journal of molecular sciences · 2023Review
- The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements.Haematologica · 2022Article
- Hyperoside Protects HK-2 Cells Against High Glucose-Induced Apoptosis and InflammationPathology oncology research : POR · 2021Article
- Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.Journal of the American Society of Nephrology : JASN · 2018Review
- Flexible small molecular anti-estrogens with N,N-dialkylated-2,5-diethoxy-4-morpholinoaniline scaffold targets multiple estrogen receptor conformations.Cell cycle (Georgetown, Tex.) · 2017Article
- Regulation of Skeletal Muscle Plasticity by Protein Arginine Methyltransferases and Their Potential Roles in Neuromuscular Disorders.Frontiers in physiology · 2017Review
- Mitochondrial Quality Control as a Therapeutic Target.Pharmacological reviews · 2016Review
- Structural and Functional Diversity of Estrogen Receptor Ligands.Current topics in medicinal chemistry · 2015Review
- Retinoic acid actions through mammalian nuclear receptors.Chemical reviews · 2014Review
- The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals.Development (Cambridge, England) · 2013Article
- Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.Biochimica et biophysica acta · 2012Review
- Article
- Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function.Cardiovascular research · 2010Article
- Enhanced mitochondrial complex gene function and reduced liver size may mediate improved feed efficiency of beef cattle during compensatory growth.Functional & integrative genomics · 2010Article
- Minireview: role of protein methylation and demethylation in nuclear hormone signaling.Molecular endocrinology (Baltimore, Md.) · 2009Review
- A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA.Molecular and cellular biology · 2008Article
- Modulation of lysine acetylation-stimulated repressive activity by Erk2-mediated phosphorylation of RIP140 in adipocyte differentiation.Cellular signalling · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have characterized two distinct binding sites, called site 1 and site 2, in the nuclear protein RIP-140 which interact with the ligand binding domain of the estrogen receptor both in solution and when the receptor is bound to DNA. Both sites are capable of independently interacting with other nuclear receptors, including the thyroid hormone and retinoic acid receptors, but they are not identical since the interaction with retinoid X receptor is mediated primarily by site 1. The interaction is enhanced by agonists but not by antagonists, and the in vitro binding activities to a number of mutant receptors correlate with their abilities to stimulate transcription in vivo. When RIP-140 is fused to heterologous DNA binding domains, it is able to stimulate the transcription of reporter genes in both yeast and mammalian cells. Thus, RIP-140 is likely to function as a bridging protein between receptors and the basal transcription machinery and thereby stimulate the transcription of target genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.