ArticleThe EMBO journal1996
Hunchback-independent silencing of late Ubx enhancers by a Polycomb Group Response Element.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
- The activity of engrailed imaginal disc enhancers is modulated epigenetically by chromatin and autoregulation.PLoS genetics · 2023Article
- RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2.Nature communications · 2020Article
- Hierarchical recruitment of Polycomb complexes revisited.Nucleus (Austin, Tex.) · 2017Review
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
- A new world of Polycombs: unexpected partnerships and emerging functions.Nature reviews. Genetics · 2013Review
- The border between the ultrabithorax and abdominal-A regulatory domains in the Drosophila bithorax complex.Genetics · 2013Article
- Insulators target active genes to transcription factories and polycomb-repressed genes to polycomb bodies.PLoS genetics · 2013Article
- Polycomb group response elements in Drosophila and vertebrates.Advances in genetics · 2013Review
- Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment.Epigenetics & chromatin · 2011Article
- GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element.Nucleic acids research · 2003Article
- Site-specific recognition of a 70-base-pair element containing d(GA)(n) repeats mediates bithoraxoid polycomb group response element-dependent silencing.Molecular and cellular biology · 2001Article
- Review
- The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity.Molecular and cellular biology · 2001Article
- Structure of a polycomb response element and in vitro binding of polycomb group complexes containing GAGA factor.Molecular and cellular biology · 2000Article
- The P-Ph protein-mediated repression of yellow expression depends on different cis- and trans-factors in Drosophila melanogaster.Genetics · 1999Article
- Trithorax- and Polycomb-group response elements within an Ultrabithorax transcription maintenance unit consist of closely situated but separable sequences.Molecular and cellular biology · 1999Article
- Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes.Genetics · 1999Article
- Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis.The EMBO journal · 1998Article
- Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin.Genes & development · 1998Article
- Polycomb group repression is blocked by the Drosophila suppressor of Hairy-wing [su(Hw)] insulator.Genetics · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila homeotic genes are kept silent outside of their appropriate expression domains by a repressive chromatin complex formed by the Polycomb Group proteins. In the case of the Ubx gene, it has been proposed that the early repressor HB, binding at enhancers, recruits the Polycomb complex and specifies the domain of repression. We show that some Ubx enhancers are activated after blastoderm. If a Polycomb Response Element (PRE) is combined with such late enhancers, repression of a reporter gene can be established everywhere in the embryo, irrespective of the presence or absence of hunchback protein. If, however, these late enhancers are combined with a Ubx early enhancer, as well as a PRE, repression is established only where the reporter gene was inactive at early stages. These results imply that the Polycomb complex is not dependent on hunchback and suggest that the pattern of silencing reflects rather the state of activity of the gene at the time the Polycomb complex is formed.
Indexed as
Identifiers
8887562PMC452203W2341128648What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.