ArticleThe EMBO journal1996
Ras signaling in tumor necrosis factor-induced apoptosis.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 77 citations in OpenAlex.
- Circulating microRNAs as markers for scrub typhus-associated acute kidney injury.Kidney research and clinical practice · 2024Article
- Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors.Cell death discovery · 2015Article
- The inside mystery of jejunal gastrointestinal stromal tumor: a rare case report and review of the literature.Case reports in oncological medicine · 2011Article
- Modulation of tumor necrosis factor-mediated cell death by fullerenes.Pharmaceutical research · 2008Article
- Pro-apoptotic activity of oncogenic H-Ras for histone deacetylase inhibitor to induce apoptosis of human cancer HT29 cells.Journal of cancer research and clinical oncology · 2007Article
- Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38.Molecular and cellular biology · 2002Article
- TNF ligands and receptors--a matter of life and death.British journal of pharmacology · 2002Review
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- A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.Oncogene · 2001Article
- Kinases: positive and negative regulators of apoptosis.Leukemia · 2000Review
- Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death.The Journal of experimental medicine · 2000Article
- TNF-induced signaling in apoptosis.Journal of clinical immunology · 1999Review
- Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.Molecular biology of the cell · 1999Article
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- Ceramide inhibits inwardly rectifying K+ currents via a Ras- and Raf-1-dependent pathway in cultured oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Histopathological evaluation of apoptosis in cancer.The American journal of pathology · 1998Review
- Inhibition of apoptosis by the actin-regulatory protein gelsolin.The EMBO journal · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Tumor necrosis factor (TNF) exerts cytotoxicity on many types of tumor cells but not on normal cells. The molecular events leading to cell death triggered by TNF are still poorly understood. Our previous studies have shown that enforced expression of an activated H-ras oncogene converted non-tumorigenic, TNF-resistant C3H 10T1/2 fibroblasts into tumorigenic cells that also became very sensitive to TNF-induced apoptosis. This finding suggested that Ras activation may play a role in TNF-induced apoptosis. In this study we investigated whether Ras activation is an obligatory step in TNF-induced apoptosis. Introduction of two different molecular antagonists of Ras, the rap1A tumor suppressor gene or the dominant-negative rasN17 gene, into H-ras-transformed 10TEJ cells inhibited TNF-induced apoptosis. Similar results were obtained with L929 cells, a fibroblast cell line sensitive to TNF-induced apoptosis, which does not have a ras mutation. While Ras is constitutively activated in TNF-sensitive 10TEJ cells, TNF treatment increased Ras-bound GTP in TNF-sensitive L929 cells but not in TNF-resistant 10T1/2 cells. Moreover, RasN17 expression blocked TNF-induced Ras-GTP formation in L929 cells. These results demonstrate that Ras activation is required for TNF-induced apoptosis in mouse fibroblasts.
Indexed as
Identifiers
8887541PMC452179W152667517What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.