ArticleThe EMBO journal1996
The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 108 citations in OpenAlex.
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Alternative splicing of squid is associated with sex-ratio allocation in the wasp Copidosomopsis nacoleiae.BMC genomics · 2025Article
- Article
- Rewiring the Sex-Determination Pathway During the Evolution of Self-Fertility.Molecular biology and evolution · 2024Article
- Sex Determination in Nematode Germ Cells.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022Review
- CAPN6 in disease: An emerging therapeutic target (Review).International journal of molecular medicine · 2020Review
- Hemimetabolous insects elucidate the origin of sexual development via alternative splicing.eLife · 2019Article
- An anti-CAPN5 intracellular antibody acts as an inhibitor of CAPN5-mediated neuronal degeneration.Oncotarget · 2017Article
- Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.Journal of structural biology · 2016Article
- Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies.The Journal of biological chemistry · 2014Article
- The evolutionary origins and consequences of self-fertility in nematodes.F1000prime reports · 2014Review
- Crossover distribution and frequency are regulated by him-5 in Caenorhabditis elegans.Genetics · 2012Article
- Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration.PLoS genetics · 2012Article
- The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration.PLoS genetics · 2012Article
- Calpain chronicle--an enzyme family under multidisciplinary characterization.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2011Review
- A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide polymorphism in tra-3.PLoS genetics · 2007Article
- Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels.BMC medical genetics · 2007Article
- Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites.Journal of molecular evolution · 2005Article
- Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene.Molecular and cellular biology · 2005Article
- Homodimerization of calpain 3 penta-EF-hand domain.The Biochemical journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Caenorhabditis elegans sex determination gene tra-3 is required for the correct sexual development of the soma and germ line in hermaphrodites, while being fully dispensable in males. Genetic analysis of tra-3 has suggested that its product may act as a potentiator of another sex determination gene, tra-2. Molecular analysis reported here reveals that the predicted tra-3 gene product is a member of the calpain family of calcium-regulated cytosolic proteases, though it lacks the calcium binding regulatory domain. Calpains are regulatory processing proteases, exhibiting marked substrate specificity, and mutations in the p94 isoform underlie the human hereditary condition limb-girdle muscular dystrophy type 2A. The molecular identity of TRA-3 is consistent with previous genetic analysis which suggested that tra-3 plays a very selective modulatory role and is required in very small amounts. Based on these observations and new genetic data, we suggest a refinement of the position of tra-3 within the sex determination cascade and discuss possible mechanisms of action for the TRA-3 protein.
Indexed as
Identifiers
8887539PMC452177W1708152313What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.