ArticleJournal of gastroenterology1996
Osteodystrophy in patients with chronic hepatitis and liver cirrhosis.
Article in Journal of gastroenterology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 81 citations in OpenAlex.
- Is it time to Reassess The Role of Preoperative HypoalbuminemiaAmong Geriatric Distal Femur Fracture Patients?Archives of orthopaedic and trauma surgery · 2024Article
- Vitamin D deficiency in patients with chronic hepatitis D viral infection.Clinical and experimental hepatology · 2021Article
- Prevalence of Liver Fibrosis and its Association with Non-invasive Fibrosis and Metabolic Markers in Morbidly Obese Patients with Vitamin D Deficiency.Obesity surgery · 2016Article
- Hypoalbuminemia and Osteoporosis: Reappraisal of a Controversy.The Journal of clinical endocrinology and metabolism · 2016Observational
- Osteoporosis and fractures in liver disease: relevance, pathogenesis and therapeutic implications.World journal of gastroenterology · 2014Review
- Vitamin D deficiency in reproductive age Mongolian women: a cross sectional study.The Journal of steroid biochemistry and molecular biology · 2014Article
- Article
- Hormonal and cytokine implications in the pathophysiology of osteoporosis occurring in chronic liver diseases.Maedica · 2012Article
- Theoretical basis of a beneficial role for vitamin D in viral hepatitis.World journal of gastroenterology · 2012Review
- Chronic non-cholestatic liver disease is not associated with an increased fracture rate in children.Journal of bone and mineral metabolism · 2011Article
- Prevalence of vitamin D deficiency in chronic liver disease.Digestive diseases and sciences · 2010Article
- Disturbances of parathyroid hormone-vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study.Hepatology international · 2010Article
- Current understanding of osteoporosis associated with liver disease.Nature reviews. Gastroenterology & hepatology · 2009Review
- Viral hepatitis is associated with reduced bone mineral density in HIV-infected women but not men.AIDS (London, England) · 2009Article
- Bone mineral density and disorders of mineral metabolism in chronic liver disease.World journal of gastroenterology · 2009Article
- Use of calcaneal ultrasound and biochemical markers to assess the density and metabolic state of the bones of adults with hepatic cirrhosis.Journal of the National Medical Association · 2007Article
- Ribavirin enhances osteoclast formation through osteoblasts via up-regulation of TRANCE/RANKL.Molecular and cellular biochemistry · 2007Article
- Bone mineral density in children with cirrhosis.Journal of gastroenterology · 2006Article
- Bone disorders in experimentally induced liver disease in growing rats.World journal of gastroenterology · 2005Article
- Bone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis?BMC gastroenterology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone mineral density (BMD) of the lumber vertebrae and factors related to bone metabolism were determined in patients with chronic viral hepatitis and patients with liver cirrhosis to clarify correlations between hepatic dysfunction, considered to be one of the causes of hepatic osteodystrophy, and decrease in bone mass. BMD of the second to fourth lumbar vertebrae was determined with a Lunar (Madison, WI, USA) DPX, a dual-energy X-ray absorptiometry diagnostic system. BMD was significantly lowest in patients with liver cirrhosis, followed by patients with chronic hepatitis, and healthy subjects, in this order. There was a significantly positive but weak correlation between albumin and BMD. Levels of 25(OH)D and 1,25(OH)2D were significantly lower in patients with liver cirrhosis than in those with chronic hepatitis. BMD and vitamin D were decreased in all patients whose cholinesterase (ChE) was below 0.3 delta pH. Urinary pyridinoline (Upyr) was significantly higher in the patients with liver cirrhosis, in whom bone mass was decreased, than in the patients with chronic hepatitis, whereas serum osteocalcin levels were distributed in the upper normal range in patients with chronic hepatitis and those with liver cirrhosis. There was a positive correlation between 25(OH)D and serum osteocalcin levels in patients with liver cirrhosis. These results indicate that osteogenesis is decreased and suggest that the decrease in BMD which occurs in viral liver cirrhosis, probably related to decreased, bone formation and slight promotion of bone resorption, reflects deranged hepatic function. This is the first report of Upyr and urinary deoxypyridinoline (UDpyr) determination in patients with liver cirrhosis and patients with chronic hepatitis. The negative correlation of Upyr and UDpyr with ChE is a novel finding.
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