ArticleBritish journal of pharmacology1996
Characterization of alpha 1 D-adrenoceptor subtype in rat myocardium, aorta and other tissues.
Article in British journal of pharmacology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 82 citations in OpenAlex.
- Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration.Frontiers in nutrition · 2022Article
- Altered expression profile of renal α(1D)-adrenergic receptor in diabetes and its modulation by PPAR agonists.Journal of diabetes research · 2014Article
- alpha-Adrenoceptor-mediated depletion of phosphatidylinositol 4, 5-bisphosphate inhibits activation of volume-regulated anion channels in mouse ventricular myocytes.British journal of pharmacology · 2010Article
- Inhibitory effect of fentanyl on phenylephrine-induced contraction of the rat aorta.Yonsei medical journal · 2009Article
- Smooth muscle alpha1D-adrenoceptors mediate phenylephrine-induced vasoconstriction and increases in endothelial cell Ca2+ in hamster cremaster arterioles.British journal of pharmacology · 2008Article
- Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction.American journal of physiology. Heart and circulatory physiology · 2008Article
- Alpha-1-adrenoceptor subtype selective regulation of connexin 43 expression in rat cardiomyocytes.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate.British journal of pharmacology · 2006Review
- Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens.British journal of pharmacology · 2004Article
- The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction.The Journal of clinical investigation · 2002Article
- Investigation of the subtypes of alpha1-adrenoceptor mediating contractions of rat vas deferens.British journal of pharmacology · 1999Article
- Functional evidence of alpha1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats.British journal of pharmacology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. This study was done to characterize the functional role of alpha 1D-adrenoceptors in rat myocardium, aorta, spleen, vas deferens and prostate by use of the selective antagonist BMY 7378. 2. BMY 7378 inhibited [3H]-prazosin binding to aortic membranes with a potency (pKi 9.8 +/- 0.40) approximately 100 fold higher than in right ventricular membranes (pKi 7.47 +/- 0.11) and approximately 1,000 fold higher than that in plasma membranes of the prostate (pKi 6.62 +/- 0.39), vas deferens (pKi 6.67 +/- 0.15), salivary gland (pKi 6.46 +/- 0.38) and liver (6.58 +/- 0.06). 3. BMY 7378 antagonized the positive inotropic effects of phenylephrine (in the presence of 1 microM propranolol) on right ventricles (pA2 7.0 +/- 0.11), left atria (pKB 7.04 +/- 0.18) and papillary muscles (pKB 6.9 +/- 0.1) and inhibited phenylephrine-induced increase in inositol phosphates. 4. BMY 7378 was approximately 100 fold more potent as an antagonist of phenylephrine on aortic strips (pA2 9.0 +/- 0.13) than on vas deferens (pKB 7.17 +/- 0.08) and spleen (pKB 7.16 +/- 0.21); it was ineffective on the prostate. 5. Chloroethylclonidine suppressed the maximal effects of phenylephrine on spleen; 5-methylurapidil antagonized the effects of phenylephrine on aortic strips (pA2 7.98 +/- 0.08), vas deferens (pKB 8.89 +/- 0.07) and prostate (pKB 8.85 +/- 0.21). 6. BMY 7378 caused a dose (0.1-100 nmol kg-1)-dependent decrease in mean blood pressure of urethane-anaesthetized rats and its hypotensive efficacy was equal to that of hexamethonium. 7. The data suggest that alpha 1D-adrenoceptors play a significant role in rat aorta, a minor role in the heart, vas deferens and spleen and virtually no role in the prostate.
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