ArticleMolecular biology of the cell1996
Telomerase regulation during entry into the cell cycle in normal human T cells.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 198 citations in OpenAlex.
- Trial
- La1: an evolutionarily conserved player in the Arabidopsis telomerase complex.Plant cell reports · 2026Article
- Extended replicative lifespan of primary resting T cells by CRISPR/dCas9-based epigenetic modifiers and transcriptional activators.Cellular and molecular life sciences : CMLS · 2024Article
- Regulation of telomerase towards tumor therapy.Cell & bioscience · 2023Review
- Promoter CpG methylation inhibits Krüppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells.Biochemistry and biophysics reports · 2021Article
- Cost-Effective Trap qPCR Approach to Evaluate Telomerase Activity: an Important Tool for Aging, Cancer, and Chronic Disease Research.Clinics (Sao Paulo, Brazil) · 2021Article
- Telomerase and telomeres in aging theory and chronographic aging theory (Review).Molecular medicine reports · 2020Review
- Stress and immunosenescence: The role of telomerase.Psychoneuroendocrinology · 2019Review
- Short telomere syndromes cause a primary T cell immunodeficiency.The Journal of clinical investigation · 2018Article
- Characterization in humans ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- The fetal programming of telomere biology hypothesis: an update.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure.Archives of toxicology · 2017Article
- Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics.Cellular and molecular life sciences : CMLS · 2015Review
- Krüppel-like factor 2 represses transcription of the telomerase catalytic subunit human telomerase reverse transcriptase (hTERT) in human T cells.The Journal of biological chemistry · 2015Article
- A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.PloS one · 2013Article
- Dyskeratosis Congenita Dermal Fibroblasts are Defective in Supporting the Clonogenic Growth of Epidermal Keratinocytes.Aging and disease · 2012Article
- Review
- Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes.PLoS genetics · 2012Article
- Aging and immune function: molecular mechanisms to interventions.Antioxidants & redox signaling · 2011Review
- Aging of the subventricular zone neural stem cell niche.Aging and disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Telomerase activity is involved in telomere length maintenance. Leukocytes, unlike many human somatic tissues, have detectable telomerase activity. These cells provide a normal human cell type in which to study telomerase. We studied the regulation of telomerase activity and the telomerase RNA component as leukocytes were stimulated to enter the cell cycle. In primary human leukocytes stimulated with phytohemagglutinin, telomerase activity increased > 10-fold as naturally quiescent cells entered the cell cycle. Antibodies to the T cell receptor (TCR)/CD3 complex and the costimulatory CD28 receptor induced telomerase activity in a T cell-enriched population of cells. Rapamycin, an immunosuppressant that blocks TCR/CD3 signal transduction pathways and cdk2 activation, blocked telomerase induction. Hydroxyurea, an inhibitor of S phase, did not block cdk2 kinase activity or telomerase activation. In summary, telomerase is regulated in G1 phase as normal human T cells enter the cell cycle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.