ArticleMolecular biology of the cell1996
Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Review
- A Genome-Wide Screen Reveals That Endocytic Genes Are Important for Pma1p Asymmetry during Cell Division inInternational journal of molecular sciences · 2022Article
- Let it go: mechanisms that detach myosin V from the yeast vacuole.Current genetics · 2021Review
- Article
- Early protection to stress mediated by CDK-dependent PI3,5PThe Journal of cell biology · 2017Article
- Target of rapamycin signaling mediates vacuolar fragmentation.Current genetics · 2017Review
- Organelle Size Scaling of the Budding Yeast Vacuole by Relative Growth and Inheritance.Current biology : CB · 2016Article
- Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.Biochemical Society transactions · 2016Review
- Programmed cell death 50 (and beyond).Cell death and differentiation · 2016Review
- Article
- Organelle size scaling of the budding yeast vacuole is tuned by membrane trafficking rates.Biophysical journal · 2014Article
- Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements.Molecular biology of the cell · 2012Article
- Infection-associated nuclear degeneration in the rice blast fungus Magnaporthe oryzae requires non-selective macro-autophagy.PloS one · 2012Article
- Identification of autophagy genes participating in zinc-induced necrotic cell death in Saccharomyces cerevisiae.Autophagy · 2011Article
- Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing.Genetics · 2010Article
- Article
- How peroxisomes multiply.Journal of cell science · 2009Review
- PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex.Molecular biology of the cell · 2009Article
- The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion.Molecular biology of the cell · 2008Article
- Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae.Biochimica et biophysica acta · 2007Review
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Authors and funding
8 authors.
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Abstract
In Saccharomyces cerevisiae the vacuoles are partitioned from mother cells to daughter cells in a cell-cycle-coordinated process. The molecular basis of this event remains obscure. To date, few yeast mutants had been identified that are defective in vacuole partitioning (vac), and most such mutants are also defective in vacuole protein sorting (vps) from the Golgi to the vacuole. Both the vps mutants and previously identified non-vps vac mutants display an altered vacuolar morphology. Here, we report a new method to monitor vacuole inheritance and the isolation of six new non-vps vac mutants. They define five complementation groups (VAC8-VAC12). Unlike mutants identified previously, three of the complementation groups exhibit normal vacuolar morphology. Zygote studies revealed that these vac mutants are also defective in intervacuole communication. Although at least four pathways of protein delivery to the vacuole are known, only the Vps pathway seems to significantly overlap with vacuole partitioning. Mutants defective in both vacuole partitioning and endocytosis or vacuole partitioning and autophagy were not observed. However, one of the new vac mutants was additionally defective in direct protein transport from the cytoplasm to the vacuole.
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