ArticleMolecular biology of the cell1996
TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 80 citations in OpenAlex.
- DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation.Nucleic acids research · 2019Article
- Inhibition of miR-9 attenuates fibroblast proliferation in human hyperplastic scar by regulating TGF-β1.American journal of translational research · 2019Article
- TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions.Molecular cancer research : MCR · 2019Article
- CCT6A suppresses SMAD2 and promotes prometastatic TGF-β signaling.The Journal of clinical investigation · 2017Article
- Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis.Autophagy · 2015Article
- pRb-E2F signaling in life of mesenchymal stem cells: Cell cycle, cell fate, and cell differentiation.Genes & diseases · 2014Review
- Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation.The Journal of clinical investigation · 2014Article
- Article
- Transforming growth factor-β regulates the growth of valve interstitial cells in vitro.The American journal of pathology · 2011Article
- Targeting the RB-pathway in cancer therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction.Molecular and cellular biology · 2010Article
- A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development.Molecular and cellular biology · 2009Article
- Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity.The Journal of biological chemistry · 2008Article
- Tailoring to RB: tumour suppressor status and therapeutic response.Nature reviews. Cancer · 2008Review
- Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches.Journal of anatomy · 2008Review
- KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor.Blood · 2008Article
- Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?Cell division · 2007Article
- HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation.The EMBO journal · 2007Article
- The retinoblastoma protein regulates pericentric heterochromatin.Molecular and cellular biology · 2006Article
- Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy.Oncogene · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor beta (TGF beta) inhibits cell proliferation by inducing a G1 cell-cycle arrest. Cyclin/CDK complexes have been implicated in this arrest, because TGF beta treatment leads to inhibition of cyclin/CDK activity. We have investigated the role of the retinoblastoma protein (pRb) in TGF beta-induced growth arrest by using RB+/+ and RB-/- primary mouse embryo fibroblasts. In both of these cell types, TGF beta inhibits CDK4-associated kinase activity. However, whereas CDK2-associated kinase activity was completely inhibited by TGF beta in the wild-type cells, it was reduced only slightly in the RB mutant cells. In addition, at high-cell density the growth-inhibitory effects of TGF beta are no longer observed in the RB-/- cells; on the contrary, TGF beta treatment promotes the growth of these mutant fibroblasts. Thus, under certain cellular growth conditions, elimination of pRb transforms the growth-inhibitory effects of TGF beta into growth-stimulatory effects. These observations could help to explain why TGF beta is often found to enhance tumorigenicity in vivo and why inactivation of the RB gene leads to tumorigenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.