ArticleBritish journal of cancer1996
Colocalisation of matrix metalloproteinase-9-mRNA and protein in human colorectal cancer stromal cells.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 62 citations in OpenAlex.
- Berberine as a potential agent for breast cancer therapy.Frontiers in oncology · 2022Review
- Activated macrophages promote invasion by early colorectal cancer via an interleukin 1β-serum amyloid A1 axis.Cancer science · 2021Article
- Overexpression of matrix metalloproteinase-21 is associated with poor overall survival of patients with colorectal cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Article
- Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9.Experimental and therapeutic medicine · 2010Article
- Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells.Molecules (Basel, Switzerland) · 2008Article
- Matrix metalloproteinase-9 expression in the normal mucosa-adenoma-dysplasia-adenocarcinoma sequence of the colon.Pathology oncology research : POR · 2008Article
- Tissue levels of active matrix metalloproteinase-2 and -9 in colorectal cancer.British journal of cancer · 2002Article
- Metastatic and non-metastatic colorectal cancer (CRC) cells induce host metalloproteinase production in vivo.Clinical & experimental metastasis · 1999Article
- Proteolysis in colorectal cancer.Molecular pathology : MP · 1999Article
- Unique activation of matrix metalloproteinase-9 within human liver metastasis from colorectal cancer.British journal of cancer · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The matrix metalloproteinases (MMPs) are perceived as essential for tumour invasion and metastases. The purpose of this study was to determine the expression and cellular localisation of the 92 kDa type IV collagenase (MMP-9) protein and mRNA in human colorectal cancer (CRC). In CRC and matched normal mucosa specimens from 26 CRC patients, Northern blot hybridisation and Western blot analyses provide convincing evidence that MMP-9 is expressed in greater quantities in CRC than in normal tissue. The MMP-9 tumour to normal mucosa fold-increase (T/N) was 9.7 +/- 7.1 (mean +/- s.d.) (P < 0.001) for RNA and 7.1 +/- 3.9 (P < 0.001) for protein. The sites of MMP-9 mRNA and protein synthesis were colocalised in tumour stroma by in situ hybridisation and immunohistochemistry in 26 CRC samples. Both MMP-9 mRNA and protein signals were strongest in the population of stromal cells concentrated at the tumour-stroma interface of an invading tumour. Furthermore, MMP-9-positive cells were identified as macrophages using an antimacrophage antibody (KP1) in serial sections from ten CRC samples. Given the persistent localisation of MMP-9-producing macrophages to the interphase between CRC and surrounding stroma, our observations suggest that MMP-9 production is controlled, in part, by tumour-stroma cell interactions. Further studies are needed to determine the in vivo regulation of MMP-9 production from infiltrating peritumour macrophages.
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