ArticleBritish journal of pharmacology1996
Nitric oxide-mediated relaxation without concomitant changes in cyclic GMP content of rat proximal colon.
Article in British journal of pharmacology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 43 citations in OpenAlex.
- Tonic inhibitory action by nitric oxide on spontaneous mechanical activity in rat proximal colon: involvement of cyclic GMP and apamin-sensitive K+ channels.British journal of pharmacology · 1999Article
- Neural modulation of the cyclic electrical and mechanical activity in the rat colonic circular muscle: putative role of ATP and NO.British journal of pharmacology · 1999Article
- Pranidipine, a new 1,4-dihydropyridine calcium channel blocker, enhances cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta.Molecular and cellular biochemistry · 1998Article
- VIP- and PACAP-mediated nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels.British journal of pharmacology · 1996Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We studied the relation of nitric oxide-mediated relaxation of longitudinal muscle to changes in cyclic GMP content of the tissue in the proximal colon of rats. 2. Dimethylphenylpiperazinium (DMPP) and electrical field stimulation (EFS) induced nitric oxide-mediated relaxation of the segments with a concomitant increase in cyclic GMP content. 3. LY 83583 and methylene blue, soluble guanylyl cyclase inhibitors, significantly inhibited the stimulatory effects of DMPP and EFS on the cyclic GMP content, but did not affect the relaxant responses of the segments to DMPP and EFS. 4. Rp-8 bromo cyclic GMPS, an inhibitor of cyclic GMP-dependent protein kinase had no effect on DMPP- and EFS-induced relaxation. 5. These data strongly suggested that nitric oxide-mediated relaxation of the rat proximal colon is not associated with change in cyclic GMP content of the tissue.
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