ReviewAnnals of the rheumatic diseases1996
Genetics of osteoarthritis.
Review in Annals of the rheumatic diseases, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 92 citations in OpenAlex.
- Nucleic acid-based therapeutics to restore joint homeostasis in age-related and post-traumatic arthritis.npj biomedical innovations · 2026Review
- Familial risks of five types of osteoarthritis in first-, second- and third-degree relatives - A nationwide Swedish family study.Osteoarthritis and cartilage open · 2025Article
- Involvement of the gene encoding the collagen type II alpha 1 chain in mandibular mobility.BMC oral health · 2025Article
- Dissect Gender-Dependent Susceptibility SNPs in Progressive Osteoarthritis Using Regulator Motif Candidate of Genetic Association Strategy (RMCGA).International journal of molecular sciences · 2025Article
- Finding the Goldilocks Zone of Mechanical Loading: A Comprehensive Review of Mechanical Loading in the Prevention and Treatment of Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2024Review
- The Role of Nutrition in Osteoarthritis Development.Nutrients · 2023Article
- Demographic and radiographic factors for knee symptoms and range of motion in patients with knee osteoarthritis: a cross-sectional study in Beijing, China.BMC musculoskeletal disorders · 2023Article
- Erosive hand osteoarthritis: latest findings and outlook.Nature reviews. Rheumatology · 2022 · on this mapReview
- Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models.Biology · 2020Review
- TBS result is not affected by lumbar spine osteoarthritis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Genetic influences on hand osteoarthritis in Finnish women--a replication study of candidate genes.PloS one · 2014Article
- Joint and bone assessment in hand osteoarthritis.Clinical rheumatology · 2014Review
- Role of interleukin-1 inhibitors in osteoarthritis: an evidence-based review.Drugs & aging · 2012Review
- Etiology of osteoarthritis: genetics and synovial joint development.Nature reviews. Rheumatology · 2012Review
- Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids.International journal of rheumatology · 2011Article
- Risk factors for radiographic tibiofemoral knee osteoarthritis: the wuchuan osteoarthritis study.International journal of rheumatology · 2010Article
- The effect of a manual therapy knee protocol on osteoarthritic knee pain: a randomised controlled trial.The Journal of the Canadian Chiropractic Association · 2008Article
- Genetics in osteoarthritis.Current genomics · 2008Article
- Weight changes and the risk of knee osteoarthritis requiring arthroplasty.Annals of the rheumatic diseases · 2004Article
- Prevalence of joint pain is higher among women in rural Japan than urban Japanese-American women in Hawaii.Annals of the rheumatic diseases · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The available evidence suggests that genetic factors have a major role in osteoarthritis. It has been believed for over 50 years that a strong genetic component to certain forms of osteoarthritis is present. This genetic influence has now been estimated to be up to 65% in a recent twin study. The nature of the genetic influence in osteoarthritis is speculative and may involve either a structural defect (that is, collagen), alterations in cartilage or bone metabolism, or alternatively a genetic influence on a known risk factor for osteoarthritis such as obesity. Exciting work has showed that mutations in the collagen type 2 are important in some rare, familial forms of osteoarthritis. Further work is needed on isolating the gene or genes involved in the pathogenesis of this common, disabling condition.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.