ArticleJournal of medical genetics1996
Prediction of psychological functioning one year after the predictive test for Huntington's disease and impact of the test result on reproductive decision making.
Article in Journal of medical genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The psychological impact of predictive genetic testing for Huntington's disease: a systematic review of the literature.Journal of genetic counseling · 2015Pooled it
- Methodology in longitudinal studies on psychological effects of predictive DNA testing: a review.Journal of medical genetics · 2004Pooled it
- Comparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2008Trial
- Psychiatric and Psychosocial Characteristics of a Cohort of Spanish Individuals Attending Genetic Counseling Due to Risk for Genetically Conditioned Dementia.Journal of Alzheimer's disease reports · 2022Article
- Genetic counselling and testing for inherited dementia: single-centre evaluation of the consensus Italian DIAfN protocol.Alzheimer's research & therapy · 2020Article
- Coping Mechanisms, Psychological Distress, and Quality of Life Prior to Cancer Genetic Counseling.Frontiers in psychology · 2018Article
- Suicidal Ideation Assessment in Individuals with Premanifest and Manifest Huntington Disease.Journal of Huntington's disease · 2018Article
- "It was an Emotional Baby": Previvors' Family Planning Decision-Making Styles about Hereditary Breast and Ovarian Cancer Risk.Journal of genetic counseling · 2017Article
- The Confluence of Psychiatric Symptoms and Neurodegenerative Disease: Impact on Genetic Counseling.Journal of genetic counseling · 2017Article
- Facilitators and Challenges in Psychosocial Adaptation to Being at Increased Familial Risk of Breast Cancer.Journal of genetic counseling · 2015Article
- Psychological Impact of Predictive Genetic Testing in VCP Inclusion Body Myopathy, Paget Disease of Bone and Frontotemporal Dementia.Journal of genetic counseling · 2015Article
- Longitudinal interviews of couples diagnosed with diminished ovarian reserve undergoing fragile X premutation testing.Journal of genetic counseling · 2014Article
- Reproductive Decision Making and Genetic Predisposition to Sudden Cardiac Death.AJOB primary research · 2012Article
- Perceived stress in prodromal Huntington disease.Psychology & health · 2012Article
- Impact of presymptomatic genetic testing for familial amyotrophic lateral sclerosis.Genetics in medicine : official journal of the American College of Medical Genetics · 2011Article
- "In sickness and in health"? Disclosures of genetic risks in dating.Journal of genetic counseling · 2011Article
- What were you thinking?: individuals at risk for Huntington Disease talk about having children.Journal of genetic counseling · 2010Article
- Long-term outcome of presymptomatic testing in Huntington disease.European journal of human genetics : EJHG · 2009Article
- Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Psychological follow-up of presymptomatic genetic testing for spinocerebellar ataxia type 2 (SCA2) in Cuba.Journal of genetic counseling · 2007Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For people at risk for Huntington's disease, the anxiety and uncertainty about the future may be very burdensome and may be an obstacle to personal decision making about important life issues, for example, procreation. For some at risk persons, this situation is the reason for requesting predictive DNA testing. The aim of this paper is two-fold. First, we want to evaluate whether knowing one's carrier status reduces anxiety and uncertainty and whether it facilitates decision making about procreation. Second, we endeavour to identify pretest predictors of psychological adaptation one year after the predictive test (psychometric evaluation of general anxiety, depression level, and ego strength). The impact of the predictive test result was assessed in 53 subjects tested, using pre- and post-test psychometric measurement and self-report data of follow up interviews. Mean anxiety and depression levels were significantly decreased one year after a good test result; there was no significant change in the case of a bad test result. The mean personality profile, including ego strength, remained unchanged one year after the test. The study further shows that the test result had a definite impact on reproductive decision making. Stepwise multiple regression analyses were used to select the best predictors of the subject's post-test reactions. The results indicate that a careful evaluation of pretest ego strength, depression level, and coping strategies may be helpful in predicting post-test reactions, independently of the carrier status. Test result (carrier/ non-carrier), gender, and age did not significantly contribute to the prediction. About one third of the variance of post-test anxiety and depression level and more than half of the variance of ego strength was explained, implying that other psychological or social aspects should also be taken into account when predicting individual post-test reactions.
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Registered trials
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