ArticleThe Journal of experimental medicine1996
Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 100 citations in OpenAlex.
- New Insights into Asthma Inflammation: Focus on iNKT, MAIT, and γδT Cells.Clinical reviews in allergy & immunology · 2020Review
- The role of invariant T cells in inflammation of the skin and airways.Seminars in immunopathology · 2019Review
- Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients.Frontiers in immunology · 2018Review
- Lipid-Reactive T Cells in Immunological Disorders of the Lung.Frontiers in immunology · 2018Review
- NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.PloS one · 2017Article
- Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13.Mucosal immunology · 2011Article
- Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma.The Journal of allergy and clinical immunology · 2010Review
- Natural killer T cells are important in the pathogenesis of asthma: the many pathways to asthma.The Journal of allergy and clinical immunology · 2010Review
- Review
- Modulation of NKT cells and Th1/Th2 imbalance after alpha-GalCer treatment in progressive load-trained rats.International journal of biological sciences · 2009Article
- Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Freshly isolated Valpha24+ CD4+ invariant natural killer T cells activated by alpha-galactosylceramide-pulsed B cells promote both IgG and IgE production.Clinical and experimental immunology · 2007Article
- Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation.Nature medicine · 2006Article
- Promise and pitfalls in animal-based asthma research: building a better mousetrap.Immunologic research · 2006Review
- In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma.The Journal of experimental medicine · 2005Article
- NK T cells are a source of early interleukin-4 following infection with third-stage larvae of the filarial nematode Brugia pahangi.Infection and immunity · 2002Article
- Requirement for natural killer T (NKT) cells in the induction of allograft tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans.Infection and immunity · 2001Article
- CD4-CD8- T cells bearing invariant Valpha24JalphaQ TCR alpha-chain are decreased in patients with atopic diseases.Clinical and experimental immunology · 2000Article
- A defect in interleukin 12-induced activation and interferon gamma secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-dependent diabetes mellitus.The Journal of experimental medicine · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
CD4+ and CD8+ alpha/beta+ T cells of the T helper cell (Th)2 phenotype produce the cytokines IL-4, IL-5, and IL-13 that promote IgE production and eosinophilic inflammation. IL-4 may play an important role in mediating the differentiation of antigenically naive alpha/beta+ T cells into Th2 cells. Murine NK1.1+ (CD4+ or CD4-CD8-) alpha/beta+ T cells comprise a beta 2-microglobulin (beta 2m)-dependent cell population that rapidly produces IL-4 after cell activation in vitro and in vivo and has been proposed as a source of IL-4 for Th2 cell differentiation. alpha/beta+ CD8+ T cells, most of which require beta 2m for their development, have also been proposed as positive regulators of allergen-induced Th2 responses. We tested whether beta 2m-dependent T cells were essential for Th2 cell-mediated allergic reactions by treating wild-type, beta 2m-deficient (beta 2m -/-), and IL-4-deficient (IL-4 -/-) mice of the C57BL/6 genetic background with ovalbumin (OVA), using a protocol that induces robust allergic pulmonary disease in wild-type mice. OVA-treated beta 2m -/- mice had circulating levels of total and OVA-specific IgE, pulmonary eosinophilia, and expression of IL-4, IL-5, and IL-13 mRNA in bronchial lymph node tissue similar to that of OVA-treated wild-type mice. In contrast, these responses in OVA-treated IL-4 -/- mice were all either undetectable or markedly reduced compared with wild-type mice, confirming that IL-4 was required in this allergic model. These results indicate that the NK1.1+ alpha/beta+ T cell population, as well as other beta 2m-dependent populations, such as most peripheral alpha/beta+ CD8+ T cells, are dispensable for the Th2 pulmonary response to protein allergens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.