ArticleGenetics1996
gutfeeling, a Drosophila gene encoding an antizyme-like protein, is required for late differentiation of neurons and muscles.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers.Science advances · 2020Article
- The role of polyamines in protein-dependent hypoxic tolerance of Drosophila.BMC physiology · 2008Article
- Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.Nucleic acids research · 2007Review
- Gain-of-function screen for genes that affect Drosophila muscle pattern formation.PLoS genetics · 2005Article
- Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila.Genetics · 2003Article
- Antizyme mRNA distribution and regulation in rat small intestinal enterocytes.Digestive diseases and sciences · 2002Article
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- Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins.Genetics · 2000Article
- Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit.Nucleic acids research · 2000Review
- Two zebrafish (Danio rerio) antizymes with different expression and activities.The Biochemical journal · 2000Article
- The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes.Genetics · 1999Article
- The Drosophila gene for antizyme requires ribosomal frameshifting for expression and contains an intronic gene for snRNP Sm D3 on the opposite strand.Molecular and cellular biology · 1998Article
- DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Structure, organization and expression of the mouse ornithine decarboxylase antizyme gene.The Biochemical journal · 1997Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gutfeeling (guf) gene was uncovered in a genetic screen for genes that are required for proper development of the embryonic peripheral nervous system. Mutations in guf cause defects in growth cone guidance and fasciculation and loss of expression of several neuronal markers in the embryonic peripheral and central nervous systems. guf is required for terminal differentiation of neuronal cells. Mutations in guf also affect the development of muscles in the embryo. In the absence or guf activity, myoblasts are formed properly, but myoblast fusion and further differentiation of muscle fibers is severely impaired. The guf gene was cloned and found to encode a 21-kD protein with a significant sequence similarity to the mammalian ornithine decarboxylase antizyme (OAZ). In mammals, OAZ plays a key regulatory role in the polyamine biosynthetic pathway through its binding to, and inhibition of, ornithine decarboxylase (ODC), the first enzyme in the pathway. The elaborate regulation of ODC activity in mammals still lacks a defined developmental role and little is known about the involvement of polyamines in cellular differentiation. GUF is the first antizyme-like protein identified in invertebrates. We discuss its possible developmental roles in light of this homology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.