ArticleGenetics1996
Duplicated proteasome subunit genes in Drosophila melanogaster encoding testes-specific isoforms.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 75 citations in OpenAlex.
- Molecular mechanisms in rare proteasomopathies.EULAR rheumatology open · 2026Review
- Review
- Destruction or Reconstruction: A Subtle Liaison between the Proteolytic and Signaling Role of Protein Ubiquitination in Spermatogenesis.Advances in experimental medicine and biology · 2021Article
- Article
- Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome.Nature communications · 2019Article
- Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster.Scientific reports · 2019Article
- High-resolution cryo-EM proteasome structures in drug development.Acta crystallographica. Section D, Structural biology · 2017Article
- Adaptive evolution of testis-specific, recently evolved, clustered miRNAs in Drosophila.RNA (New York, N.Y.) · 2014Article
- Relocation facilitates the acquisition of short cis-regulatory regions that drive the expression of retrogenes during spermatogenesis in Drosophila.Molecular biology and evolution · 2014Article
- Article
- Adaptive evolution of genes duplicated from the Drosophila pseudoobscura neo-X chromosome.Molecular biology and evolution · 2010Article
- Molecular mechanisms of proteasome assembly.Nature reviews. Molecular cell biology · 2009Review
- Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis.Biological chemistry · 2008Review
- Evolutionary origin of regulatory regions of retrogenes in Drosophila.BMC genomics · 2008Article
- Analysis of the Drosophila melanogaster testes transcriptome reveals coordinate regulation of paralogous genes.Genetics · 2008Article
- Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila.Genome biology · 2007Article
- Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Identification and characterization of a Drosophila proteasome regulatory network.Molecular and cellular biology · 2005Article
- Regulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster.Nucleic acids research · 2005Article
- Rapid evolution through gene duplication and subfunctionalization of the testes-specific alpha4 proteasome subunits in Drosophila.Genetics · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using the previously cloned proteasome alpha-type subunit gene Pros28.1, we screened a Drosophila melanogaster genomic library using reduced stringency conditions to identify closely related genes. Two new genes, Pros28.1A (map position 92F) and Pros28.1B (map position 60D7), showing high sequence similarity to Pros28.1, were identified and characterized. Pros28.1A encodes a protein with 74% amino acid identity to PROS28.1, while the Pros28.1B gene product is 58% identical. The Pros28.1B gene has two introns, located in exactly analogous positions as the two introns in Pros28.1, while the Pros28.1A gene lacks introns. Northern blot analysis reveals that the two new genes are expressed only in males, during the pupal and adult stages. Tissue-specific patterns of expression were examined using transgenic flies carrying lacz-fusion reporter genes. This analysis revealed that both genes are expressed in germline cells during spermatogenesis, although their expression patterns differed. Pros28.1A expression is first detected at the primary spermatocyte stage and persists into the spermatid elongation phase of spermiogenesis, while Pros28.1B expression is prominent only during spermatid elongation. These genes represent the most striking example of cell-type-specific proteasome gene expression reported to date in any system and support the notion that there is structural and functional heterogeneity among proteasomes in metazoans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.