ArticleProceedings of the National Academy of Sciences of the United States of America1996
Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 228 citations in OpenAlex.
- Swedish population data for 37 autosomal, 12 X-chromosomal and 23 Y-chromosomal STR loci.International journal of legal medicine · 2026Article
- Blood donor biobank as a resource in personalised biomedical genetic research.European journal of human genetics : EJHG · 2024Article
- From early methods for DNA diagnostics to genomes and epigenomes at high resolution during four decades - a personal perspective.Upsala journal of medical sciences · 2024Review
- Phylogeographic history of mitochondrial haplogroup J in Scandinavia.American journal of biological anthropology · 2023Article
- Polycystic ovary syndrome and leukocyte telomere length: cross-sectional and longitudinal changes.European journal of endocrinology · 2022Article
- Blood donor biobank and HLA imputation as a resource for HLA homozygous cells for therapeutic and research use.Stem cell research & therapy · 2022Article
- Variation in the Substitution Rates among the Human Mitochondrial Haplogroup U Sublineages.Genome biology and evolution · 2022Article
- Evolution and dispersal of mitochondrial DNA haplogroup U5 in Northern Europe: insights from an unsupervised learning approach to phylogeography.BMC genomics · 2022Article
- Human Prehistoric Demography Revealed by the Polymorphic Pattern of CpG Transitions.Molecular biology and evolution · 2020Article
- Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort.NAR genomics and bioinformatics · 2020Article
- Human mitochondrial DNA lineages in Iron-Age Fennoscandia suggest incipient admixture and eastern introduction of farming-related maternal ancestry.Scientific reports · 2019Article
- Global demographic history of human populations inferred from whole mitochondrial genomes.Royal Society open science · 2018Article
- Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland.American journal of human genetics · 2018Article
- The phenotypic and molecular spectrum of PEHO syndrome and PEHO-like disorders.Brain : a journal of neurology · 2017Article
- Identification and analysis of mtDNA genomes attributed to Finns reveal long-stagnant demographic trends obscured in the total diversity.Scientific reports · 2017Article
- Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size.Molecular biology and evolution · 2017Article
- Article
- Unexpectedly High Prevalence of Common Variable Immunodeficiency in Finland.Frontiers in immunology · 2017Article
- Commonalities in Development of Pure Breeds and Population Isolates Revealed in the Genome of the Sardinian Fonni's Dog.Genetics · 2016Article
- Iron Age and Anglo-Saxon genomes from East England reveal British migration history.Nature communications · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An analysis of Y-chromosomal haplotypes in several European populations reveals an almost monomorphic pattern in the Finns, whereas Y-chromosomal diversity is significantly higher in other populations. Furthermore, analyses of nucleotide positions in the mitochondrial control region that evolve slowly show a decrease in genetic diversity in Finns. Thus, relatively few men and women have contributed the genetic lineages that today survive in the Finnish population. This is likely to have caused the so-called "Finnish disease heritage"-i.e., the occurrence of several genetic diseases in the Finnish population that are rare elsewhere. A preliminary analysis of the mitochondrial mutations that have accumulated subsequent to the bottleneck suggests that it occurred about 4000 years ago, presumably when populations using agriculture and animal husbandry arrived in Finland.
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