ArticleProceedings of the National Academy of Sciences of the United States of America1996
Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Microenvironment-feedback regulated hydrogels as living wound healing materials.Nature communications · 2025Article
- The effect of acellular scaffold loaded with Wharton's jelly-derived stem cells and mineral pitch on healing of burn model in rat.Cell and tissue banking · 2024Article
- Biodegradable, Self-Reinforcing Vascular Grafts for In Situ Tissue Engineering Approaches.Advanced healthcare materials · 2023Article
- Chorion-derived extracellular matrix hydrogel and fibronectin surface coatings show similar beneficial effects on endothelialization of expanded polytetrafluorethylene vascular grafts.Materials today. Bio · 2022Article
- Role of β-Interferon Inducer (DEAE-Dextran) in Tumorigenesis by VEGF and NOTCH1 Inhibition along with Apoptosis Induction.Frontiers in pharmacology · 2017Article
- PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis.Clinical science (London, England : 1979) · 2015Review
- Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway.Current biology : CB · 2012Article
- The glycan profile of endothelial cells in the present of tumor-conditioned medium and potential roles of beta-1,6-GlcNAc branching on HUVEC conformation.Molecular and cellular biochemistry · 2010Article
- Endothelial Src kinase regulates membrane recycling from the lateral border recycling compartment during leukocyte transendothelial migration.European journal of immunology · 2008Article
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- PECAM-1 isoform-specific functions in PECAM-1-deficient brain microvascular endothelial cells.Microvascular research · 2008Article
- Article
- Paradoxical effects of hypoxia-mimicking divalent cobalt ions in human endothelial cells in vitro.Molecular and cellular biochemistry · 2005Article
- Platelet endothelial cell adhesion molecule in cell signaling and thrombosis.Molecular and cellular biochemistry · 2003Review
- The expression of platelet endothelial cell adhesion molecule-1 in mouse primordial germ cells during their migration and early gonadal formation.Histochemistry and cell biology · 2003Article
- Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells.The American journal of pathology · 2003Article
- Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2.The Journal of cell biology · 2003Article
- PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells.The Journal of cell biology · 2002Article
- Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice.The Journal of clinical investigation · 2002Article
- Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation.The American journal of pathology · 2001Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Platelet-endothelial cell adhesion molecule 1 (PECAM-1, CD31) is a 130-kDa member of the immunoglobulin gene superfamily expressed on endothelial cells, platelets, neutrophils, and monocytes and plays a role during endothelial cell migration. Phosphoamino acid analysis and Western blot analysis with anti-phosphotyrosine antibody show that endothelial PECAM-1 is tyrosine-phosphorylated. Phosphorylation is decreased with endothelial cell migration on fibronectin and collagen and with cell spreading on fibronectin but not on plastic. Cell adhesion on anti-integrin antibodies is also able to specifically induce PECAM-1 dephosphorylation while concurrently inducing pp125 focal adhesion kinase phosphorylation. Inhibition of dephosphorylation with sodium orthovanadate suggests that this effect is at least partially mediated by phosphatase activity. Tyr-663 and Tyr-686 are identified as potential phosphorylation sites and mutated to phenylalanine. When expressed, both mutants show reduced PECAM-1 phosphorylation but Phe-686 mutants also show significant reversal of PECAM-1-mediated inhibition of cell migration and do not localize PECAM-1 to cell borders. Our results suggest that beta 1-integrin engagement can signal to dephosphorylate PECAM-1 and that this signaling pathway may play a role during endothelial cell migration.
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Registered trials
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