ArticleProceedings of the National Academy of Sciences of the United States of America1996
The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 82 citations in OpenAlex.
- Review
- The MAPK and PI3K pathways mediate CNTF-induced neuronal survival and process outgrowth in hypothalamic organotypic cultures.Journal of cell communication and signaling · 2015Article
- STAT3 signaling in pulmonary arterial hypertension.JAK-STAT · 2012Review
- JAKs go nuclear: emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth.Growth factors (Chur, Switzerland) · 2011Review
- Raf family kinases: old dogs have learned new tricks.Genes & cancer · 2011Article
- Viral oncolysis that targets Raf-1 signaling control of nuclear transport.Journal of virology · 2010Article
- CNTF-evoked activation of JAK and ERK mediates the functional expression of T-type Ca2+ channels in chicken nodose neurons.Journal of neurochemistry · 2009Article
- Role of the serine-threonine kinase PAK-1 in myxoma virus replication.Journal of virology · 2003Article
- The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia.Leukemia · 2002Review
- Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions.Oncogene · 2001Article
- JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase.Molecular and cellular biology · 2001Article
- Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.The Biochemical journal · 2000Review
- Enhancement of proliferation and differentiation of erythroid progenitors by co-transduction of erythropoietin receptor and H-ras cDNAS into single CD34(3+) cord blood cells.Bone marrow transplantation · 2000Article
- Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A.Molecular and cellular biology · 1999Article
- Complementation of defective colony-stimulating factor 1 receptor signaling and mitogenesis by Raf and v-Src.Molecular and cellular biology · 1999Article
- Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.The Biochemical journal · 1998Review
- Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.Molecular and cellular biology · 1997Article
- Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway.Molecular and cellular biology · 1997Article
- JAK2 is required for induction of the murine DUB-1 gene.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
JAK2, a member of the Janus kinase superfamily was found to interact functionally with Raf-1, a central component of the ras/mitogen-activated protein kinase signal transduction pathway. Interferon-gamma and several other cytokines that are known to activate JAK2 kinase were also found to stimulate Raf-1 kinase activity toward MEK-1 in mammalian cells. In the baculovirus coexpression system, Raf-1 was activated by JAK2 in the presence of p21ras. Under these conditions, a ternary complex of p21ras, JAK2, and Raf-1 was observed. In contrast, in the absence of p21ras, coexpression of JAK2 and Raf-1 resulted in an overall decrease in the Raf-1 kinase activity. In addition, JAK2 phosphorylated Raf-1 at sites different from those phosphorylated by pp60v-src. In mammalian cells treated with either erythropoietin or interferon-gamma, a small fraction of Raf-1 coimmunoprecipitated with JAK2 in lysates of cells in which JAK2 was activated as judged by its state of tyrosine phosphorylation. Taken together, these data suggest that JAK2 and p21ras cooperate to activate Raf-1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.