ArticleProceedings of the National Academy of Sciences of the United States of America1996
Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 90 citations in OpenAlex.
- Impact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA Interaction.Frontiers in microbiology · 2017Article
- The Mediator complex and transcription elongation.Biochimica et biophysica acta · 2013Review
- Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.Virus research · 2012Review
- Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein.Retrovirology · 2009Article
- The HIV-1 transcriptional activator Tat has potent nucleic acid chaperoning activities in vitro.Nucleic acids research · 2008Article
- Cross-interaction between JC virus agnoprotein and human immunodeficiency virus type 1 (HIV-1) Tat modulates transcription of the HIV-1 long terminal repeat in glial cells.Journal of virology · 2006Article
- Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region.Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research · 2005Article
- Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.Journal of virology · 2004Article
- FF domains of CA150 bind transcription and splicing factors through multiple weak interactions.Molecular and cellular biology · 2004Article
- Analysis of the requirement for RNA polymerase II CTD heptapeptide repeats in pre-mRNA splicing and 3'-end cleavage.RNA (New York, N.Y.) · 2004Article
- Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF.The EMBO journal · 2002Article
- RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions.Journal of virology · 2002Article
- Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes.Molecular and cellular biology · 2002Article
- Human GLI-2 is a tat activation response element-independent Tat cofactor.Journal of virology · 2001Article
- Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.Molecular and cellular biology · 2000Article
- Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.Molecular and cellular biology · 2000Article
- TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes.The EMBO journal · 2000Article
- hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.Molecular and cellular biology · 1999Article
- Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Human and rodent transcription elongation factor P-TEFb: interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate.Journal of virology · 1999Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Human immunodeficiency virus (HIV)-encoded trans-activator (Tat) acts through the trans-activation response element RNA stem-loop to increase greatly the processivity of RNA polymerase II. Without Tat, transcription originating from the HIV promoter is attenuated. In this study, we demonstrate that transcriptional activation by Tat in vivo and in vitro requires the C-terminal domain (CTD) of RNA polymerase II. In contrast, the CTD is not required for basal transcription and for the formation of short, attenuated transcripts. Thus, trans-activation by Tat resembles enhancer-dependent activation of transcription. These results suggest that effects of Tat on the processivity of RNA polymerase II require proteins that are associated with the CTD and may result in the phosphorylation of the CTD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.