ArticleProceedings of the National Academy of Sciences of the United States of America1996
CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 118 citations in OpenAlex.
- The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration.American journal of respiratory cell and molecular biology · 2025Article
- Cut homeodomain transcription factor is a novel regulator of growth and morphogenesis of cortex glia niche around neural cells.Genetics · 2024Article
- Spatiotemporal Epigenetic Control of the Histone Gene Chromatin Landscape during the Cell Cycle.Critical reviews in eukaryotic gene expression · 2023Article
- Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome.F&S science · 2021Article
- CUX1, A Controversial Player in Tumor Development.Frontiers in oncology · 2020Review
- Higher order genomic organization and regulatory compartmentalization for cell cycle control at the G1/S-phase transition.Journal of cellular physiology · 2018Review
- Competitive Promoter-Associated Matrix Attachment Region Binding of the Arid3a and Cux1 Transcription Factors.Diseases (Basel, Switzerland) · 2017Article
- CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.Nature reviews. Cancer · 2014Review
- Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients.Carcinogenesis · 2013Article
- Multilayered chromatin analysis reveals E2f, Smad and Zfx as transcriptional regulators of histones.Nature structural & molecular biology · 2013Article
- The abbreviated pluripotent cell cycle.Journal of cellular physiology · 2013Review
- CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.Nucleic acids research · 2012Article
- The architectural organization of human stem cell cycle regulatory machinery.Current pharmaceutical design · 2012Review
- Article
- Hyperphosphorylation by cyclin B/CDK1 in mitosis resets CUX1 DNA binding clock at each cell cycle.The Journal of biological chemistry · 2010Article
- p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin.The Journal of biological chemistry · 2009Article
- The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Regulation of cell proliferation and differentiation in the kidney.Frontiers in bioscience (Landmark edition) · 2009Review
- p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes.Molecular and cellular biology · 2008Article
- Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes.Nucleic acids research · 2008Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Transcription of the genes for the human histone proteins H4, H3, H2A, H2B, and H1 is activated at the G1/S phase transition of the cell cycle. We have previously shown that the promoter complex HiNF-D, which interacts with cell cycle control elements in multiple histone genes, contains the key cell cycle factors cyclin A, CDC2, and a retinoblastoma (pRB) protein-related protein. However, an intrinsic DNA-binding subunit for HiNF-D was not identified. Many genes that are up-regulated at the G1/S phase boundary are controlled by E2F, a transcription factor that associates with cyclin-, cyclin-dependent kinase-, and pRB-related proteins. Using gel-shift immunoassays, DNase I protection, and oligonucleotide competition analyses, we show that the homeodomain protein CDP/cut, not E2F, is the DNA-binding subunit of the HiNF-D complex. The HiNF-D (CDP/cut) complex with the H4 promoter is immunoreactive with antibodies against CDP/cut and pRB but not p107, whereas the CDP/cut complex with a nonhistone promoter (gp91-phox) reacts only with CDP and p107 antibodies. Thus, CDP/cut complexes at different gene promoters can associate with distinct pRB-related proteins. Transient coexpression assays show that CDP/cut modulates H4 promoter activity via the HiNF-D-binding site. Hence, DNA replication-dependent histone H4 genes are regulated by an E2F-independent mechanism involving a complex of CDP/cut with cyclin A/CDC2/ RB-related proteins.
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