ArticleProceedings of the National Academy of Sciences of the United States of America1996
Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 100 citations in OpenAlex.
- Cyclin-dependent protein kinases and cell cycle regulation in biology and disease.Signal transduction and targeted therapy · 2025Review
- WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck.Neoplasia (New York, N.Y.) · 2020Article
- An RB-Condensin II Complex Mediates Long-Range Chromosome Interactions and Influences Expression at Divergently Paired Genes.Molecular and cellular biology · 2020Article
- Aberrant Function of the C-Terminal Tail of HIST1H1E Accelerates Cellular Senescence and Causes Premature Aging.American journal of human genetics · 2019Article
- Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment.Cell cycle (Georgetown, Tex.) · 2017Article
- Linker histone H1 and protein-protein interactions.Biochimica et biophysica acta · 2016Review
- Misexpression of cyclin D1 in embryonic germ cells promotes testicular teratoma initiation.Cell cycle (Georgetown, Tex.) · 2016Article
- Linker histone partial phosphorylation: effects on secondary structure and chromatin condensation.Nucleic acids research · 2015Article
- Histone H1 phosphorylation in breast cancer.Journal of proteome research · 2014Article
- H1 histones: current perspectives and challenges.Nucleic acids research · 2013Review
- Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatin.The Journal of cell biology · 2013Article
- Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1).Cellular oncology (Dordrecht, Netherlands) · 2013Article
- Review
- Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice.Development (Cambridge, England) · 2012Article
- Histone H1 interphase phosphorylation becomes largely established in G1 or early S phase and differs in G1 between T-lymphoblastoid cells and normal T cells.Epigenetics & chromatin · 2011Article
- RB1, development, and cancer.Current topics in developmental biology · 2011Review
- Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia.Proteomics · 2010Article
- Minireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin.Molecular endocrinology (Baltimore, Md.) · 2010Review
- Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II.The Journal of cell biology · 2010Article
- pRb, a local chromatin organizer with global possibilities.Chromosoma · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibroblasts derived from embryos homozygous for a disruption of the retinoblastoma gene (Rb) exhibit a shorter G1 than their wild-type counterparts, apparently due to highly elevated levels of cyclin E protein and deregulated cyclin-dependent kinase 2 (CDK2) activity. Here we demonstrate that the Rb-/- fibroblasts display higher levels of phosphorylated H1 throughout G1 with the maximum being 10-fold higher than that of the Rb+/+ fibroblasts. This profile of intracellular H1 phosphorylation corresponds with deregulated CDK2 activity observed in in vitro assays, suggesting that CDK2 may be directly responsible for the in vivo phosphorylation of H1. H1 phosphorylation has been proposed to lead to a relaxation of chromatin structure due to a decreased affinity of this protein for chromatin after phosphorylation. In accord with this, chromatin from the Rb-/- cells is more susceptible to micrococcal nuclease digestion than that from Rb+/+ fibroblasts. Increased H1 phosphorylation and relaxed chromatin structure have also been observed in cells expressing several oncogenes, suggesting a common mechanism in oncogene and tumor suppressor gene function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.