ArticleMammalian genome : official journal of the International Mammalian Genome Society1996
Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 153 citations in OpenAlex.
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- Mechanistic and Therapeutic Insights into Ataxic Disorders with Pentanucleotide Expansions.Cells · 2022Review
- Interactions Between Purkinje Cells and Granule Cells Coordinate the Development of Functional Cerebellar Circuits.Neuroscience · 2021Review
- Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.Molecular biology reports · 2020Article
- Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation.Biomolecules · 2020Review
- Motor Performances of Spontaneous and Genetically Modified Mutants with Cerebellar Atrophy.Cerebellum (London, England) · 2019Review
- QTL and systems genetics analysis of mouse grooming and behavioral responses to novelty in an open field.Genes, brain, and behavior · 2017Article
- The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.Journal of lipid research · 2017Review
- Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex.Brain sciences · 2017Review
- Control of Neuronal Migration and Aggregation by Reelin Signaling in the Developing Cerebral Cortex.Frontiers in cell and developmental biology · 2017Review
- Canonical and Non-canonical Reelin Signaling.Frontiers in cellular neuroscience · 2016Review
- Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development.Frontiers in cellular neuroscience · 2015Review
- Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex.Science (New York, N.Y.) · 2014Article
- From mice to men: lessons from mutant ataxic mice.Cerebellum & ataxias · 2014Review
- How big is the myelinating orchestra? Cellular diversity within the oligodendrocyte lineage: facts and hypotheses.Frontiers in cellular neuroscience · 2014Review
- Neocortical neurogenesis and neuronal migration.Wiley interdisciplinary reviews. Developmental biology · 2013Review
- Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice.Frontiers in neural circuits · 2013Article
- Loss of the Reelin-signaling pathway differentially disrupts heat, mechanical and chemical nociceptive processing.Neuroscience · 2012Article
- Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone.Neural development · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A novel spontaneous neurological mutation, scrambler (scm), appeared in the inbred mouse strain DC/Le (dancer) in 1991. Mice homozygous for this recessive mutation are recognized by an unstable gait and whole-body tremor. The cerebella of 30-day-old scrambler homozygotes are hypoplastic and devoid of folia; however, neither seizures nor abnormal brain wave patterns have been observed. Homozygous scrambler mutants have an ataxic gait which in the male may be a contributory factor in the failure to mate. Female homozygotes mate and breed. Life span is not reduced in either sex. Scrambler is similar to the reeler mutation in phenotype and pathology and, like reeler, probably results from defective neuronal migration. We mapped the scrambler mutation to Chromosome (Chr) 4, proving that it is distinct from the recently cloned reeler gene on Chr 5. We also determined the map position of the agrin gene, Agrn, on Chr 4, and on this basis eliminated it as a candidate for scm. Currently there is no known homology of scrambler with human lissencephalies or other human disorders caused by abnormal neuronal migration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.