ArticleJournal of pharmacokinetics and biopharmaceutics1996
Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: application of a stochastic model to the rat hindlimb.
Article in Journal of pharmacokinetics and biopharmaceutics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
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- Comparison of distributed and compartmental models of drug disposition: assessment of tissue uptake kinetics.Journal of pharmacokinetics and pharmacodynamics · 2016Article
- Exponential tails of drug disposition curves: reality or appearance?Journal of pharmacokinetics and pharmacodynamics · 2014Article
- Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.Pharmaceutical research · 2012Article
- Pharmacokinetic analysis of continuous erythropoietin receptor activator disposition in adult sheep using a target-mediated, physiologic recirculation model and a tracer interaction methodology.Drug metabolism and disposition: the biological fate of chemicals · 2011Article
- Circulatory model of vascular and interstitial distribution kinetics of rocuronium: a population analysis in patients.Journal of pharmacokinetics and pharmacodynamics · 2011Article
- Drug structure-transport relationships.Journal of pharmacokinetics and pharmacodynamics · 2010Review
- Residence time dispersion as a general measure of drug distribution kinetics: estimation and physiological interpretation.Pharmaceutical research · 2007Article
- Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts.The AAPS journal · 2007Review
- Characterization of the physiological spaces and distribution of tolbutamide in the perfused rat pancreas.Pharmaceutical research · 2007Article
- A compartmental model of hepatic disposition kinetics: 1. Model development and application to linear kinetics.Journal of pharmacokinetics and pharmacodynamics · 2002Article
- Cytoplasmic binding and disposition kinetics of diclofenac in the isolated perfused rat liver.British journal of pharmacology · 2000Article
- An isolated in-situ rat head perfusion model for pharmacokinetic studies.Pharmaceutical research · 2000Article
- Modeling of hepatic elimination and organ distribution kinetics with the extended convection-dispersion model.Journal of pharmacokinetics and biopharmaceutics · 1999Article
- The anomalous pharmacokinetics of amiodarone explained by nonexponential tissue trapping.Journal of pharmacokinetics and biopharmaceutics · 1999Article
- Cellular pharmacokinetics: effects of cytoplasmic diffusion and binding on organ transit time distribution.Journal of pharmacokinetics and biopharmaceutics · 1999Article
- Distribution and binding kinetics of ciprofloxacin and ofloxacin in the hindlimb of the rat.Pharmaceutical research · 1999Article
- Diffusion-limited, but not perfusion-limited, compartmental models describe cerebral nitrous oxide kinetics at high and low cerebral blood flows.Journal of pharmacokinetics and biopharmaceutics · 1998Article
- Metabolite mean transit times in the liver as predicted by various models of hepatic elimination.Journal of pharmacokinetics and biopharmaceutics · 1997Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A stochastic theory of drug transport in a random capillary network with permeation across the endothelial barrier is coupled with a model of tissue residence time of drugs assuming radial intratissue diffusion. Axial diffusion is neglected both in tissue as well as in the radially well-mixed vascular phase. The convective transport through the microcirculatory network is characterized by an experimentally determined transit time distribution of a nonpermeating vascular indicator. This information is used to identify three adjustable model parameters characterizing permeation, diffusion, and steady-state distribution into tissue. Predictions are made for the influence of distribution volume, capillary permeability, and tissue diffusion on transit time distributions. The role of convection (through the random capillary network), permeation, and diffusion as determinants of the relative dispersion of organ transit times has been examined. The relationship to previously proposed models of capillary exchange is discussed. Results obtained for lidocaine in the isolated perfused hindleg in rats indicate that although the contribution of intratissue diffusion to the dispersion process is relatively small in quantitative terms, it has a pronounced influence on the shape of the impulse response curve. The theory suggests that the rate of diffusion in muscle tissue is about two orders of magnitude slower than in water.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.