ArticleBiophysical journal1996
Voltage-clamp studies of gap junctions between uterine muscle cells during term and preterm labor.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 74 citations in OpenAlex.
- β3 Receptor Signaling in Pregnant Human Myometrium Suggests a Role for β3 Agonists as Tocolytics.Biomolecules · 2023Review
- Modeling and experimental approaches for elucidating multi-scale uterine smooth muscle electro- and mechano-physiology: A review.Frontiers in physiology · 2022Review
- Uterine contractions in rodent models and humans.Acta physiologica (Oxford, England) · 2021Review
- Review and Study of Uterine Bioelectrical Waveforms and Vector Analysis to Identify Electrical and Mechanosensitive Transduction Control Mechanisms During Labor in Pregnant Patients.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Electrophysiology of Syncytial Smooth Muscle.Journal of experimental neuroscience · 2019Review
- Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells.PLoS computational biology · 2016Article
- Functional and morphological development of the womb throughout life.Science progress · 2015Review
- Intracellular Cleavage of the Cx43 C-Terminal Domain by Matrix-Metalloproteases: A Novel Contributor to Inflammation?Mediators of inflammation · 2015Review
- The role of cellular coupling in the spontaneous generation of electrical activity in uterine tissue.PloS one · 2015Article
- Alterations in gap junction connexin43/connexin45 ratio mediate a transition from quiescence to excitation in a mathematical model of the myometrium.Journal of the Royal Society, Interface · 2014Article
- Fine spatiotemporal activity in contracting myometrium revealed by motion-corrected calcium imaging.The Journal of physiology · 2014Article
- Store-operated Ca²⁺ entry and depolarization explain the anomalous behaviour of myometrial SR: effects of SERCA inhibition on electrical activity, Ca²⁺ and force.Cell calcium · 2014Article
- Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?Frontiers in pharmacology · 2013Review
- Spatial heterogeneity enhances and modulates excitability in a mathematical model of the myometrium.Journal of the Royal Society, Interface · 2013Article
- Gap junctions.Comprehensive Physiology · 2012Review
- Use of progesterone and progestin analogs for inhibition of preterm birth and other uterine contractility disorders.Facts, views & vision in ObGyn · 2012Review
- A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse.Biology of reproduction · 2009Article
- Identification of a non-selective cation channel current in myometrial cells isolated from pregnant rats.Pflugers Archiv : European journal of physiology · 2004Article
- Two distinct gating mechanisms in gap junction channels: CO2-sensitive and voltage-sensitive.Biophysical journal · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gap junctions between myometrial cells increase dramatically during the final stages of pregnancy. To study the functional consequences, we have applied the double-whole-cell voltage-clamp technique to freshly isolated pairs of cells from rat circular and longitudinal myometrium. Junctional conductance was greater between circular muscle-cell pairs from rats delivering either at term (32 +/- 16 nS, mean +/- SD, n = 128) or preterm (26 +/- 17 nS, n = 33) compared with normal preterm (4.7 +/- 7.6 nS, n = 114) and postpartum (6.5 +/- 10 nS, n = 16); cell pairs from the longitudinal layer showed similar differences. The macroscopic gap junction currents decayed slowly from an instantaneous, constant-conductance level to a steady-state level described by quasisymmetrical Boltzmann functions of transjunctional voltage. In half of circular-layer cell pairs, the voltage dependence of myometrial gap junction conductance is more apparent at smaller transjunctional voltages (< 30 mV) than for other tissues expressing mainly connexin-43. This unusual degree of voltage dependence, although slow, operates over time intervals that are physiologically relevant for uterine muscle. Using weakly coupled pairs, we observed two unitary conductance states: 85 pS (85-90% of events) and 25 pS. These measurements of junctional conductance support the hypothesis that heightened electrical coupling between the smooth muscle cells of the uterine wall emerges late in pregnancy, in preparation for the massive, coordinate contractions of labor.
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