ArticleBiophysical journal1996
A mathematical description of miniature postsynaptic current generation at central nervous system synapses.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Fusion pore flux controls the rise-times of quantal synaptic responses.The Journal of general physiology · 2024Article
- Diverging from the Norm: Reevaluating What Miniature Excitatory Postsynaptic Currents Tell Us about Homeostatic Synaptic Plasticity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses.Nature communications · 2021Article
- Functional organization of postsynaptic glutamate receptors.Molecular and cellular neurosciences · 2018Review
- Transcellular Nanoalignment of Synaptic Function.Neuron · 2017Review
- Stochastic, structural and functional factors influencing AMPA and NMDA synaptic response variability: a review.Neuronal signaling · 2017Review
- Efficient integration of synaptic events by NMDA receptors in three-dimensional neuropil.Biophysical journal · 2015Article
- Random dispersion in excitatory synapse response.Cognitive neurodynamics · 2014Article
- Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held.The Journal of physiology · 2013Article
- Mechanisms underlying signal filtering at a multisynapse contact.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.Advances in experimental medicine and biology · 2012Review
- Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract.American journal of physiology. Cell physiology · 2011Article
- Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Target-specific regulation of synaptic amplitudes in the neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Independent sources of quantal variability at single glutamatergic synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Quantal size and variation determined by vesicle size in normal and mutant Drosophila glutamatergic synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Asymmetry of glia near central synapses favors presynaptically directed glutamate escape.Biophysical journal · 2002Article
- Ultrastructural basis of synaptic transmission between endbulbs of Held and bushy cells in the rat cochlear nucleus.The Journal of physiology · 2002Article
- The role of perisynaptic glial sheaths in glutamate spillover and extracellular Ca(2+) depletion.Biophysical journal · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variation in the amplitude of miniature postsynaptic currents (mPSCs) generated by individual quanta of neurotransmitter is a major contributor to the variance of evoked synaptic responses. Here we explore the possible origins of this variability by developing a mathematical description of mPSC generation and consider the contribution of "off-center" release to this variability. By "off-center" release we mean variation in the distance between the position where a presynaptic vesicle discharges its content of neurotransmitter into the synaptic cleft and the center of a cluster of postsynaptic receptors (PRCs) that responds to those transmitter molecules by generating an mPSC. We show that when the time course of quantal discharge through a fusion pore (noninstantaneous release) is considered, elementary analytical descriptions of the subsequent diffusion of transmitter within the synaptic cleft (with or without uptake) predict the development of significant gradients of transmitter concentration during the rising phase of mPSCs. This description of diffusion is combined with a description of the pharmacodynamics of receptors in the PRC and of the time dependence of the gradient of transmitter concentration over the area of the PRC to reconstruct the time course and amplitude of an mPSC for a synapse of a given geometry. Within the constraints of known dimensions of presynaptic active zones and postsynaptic receptor clusters at CNS synapses, our analysis suggests that "off-center" release, produced by allowing release to occur anywhere within an anatomically defined presynaptic active zone, can be an important contributor to mPSC variability. Indeed, modulation of the influence of "off-center" release may be a novel way of controlling synaptic efficacy. We also show how noninstantaneous release can serve to focus the action of neurotransmitter within a given synapse and thereby reduce cross-talk between synapses.
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