ArticleInternational journal of pancreatology : official journal of the International Association of Pancreatology1996
Microsphere distribution in the pancreas of anesthetized rats. Alloxan stimulates the blood flow to all islets whereas glucose only affects the blood perfusion of a subgroup of islets.
Article in International journal of pancreatology : official journal of the International Association of Pancreatology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Pancreatic islet blood flow and its measurement.Upsala journal of medical sciences · 2016Review
- Superior beta cell proliferation, function and gene expression in a subpopulation of rat islets identified by high blood perfusion.Diabetologia · 2012Article
- Increased numbers of low-oxygenated pancreatic islets after intraportal islet transplantation.Diabetes · 2011Article
- A low-oxygenated subpopulation of pancreatic islets constitutes a functional reserve of endocrine cells.Diabetes · 2011Article
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1 author at 1 institution in 1 country.
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Abstract
conclusionIslet blood flow stimulation induced by alloxan leads to an increased blood perfusion in all islets, whereas glucose induces a flow increase only in a subgroup of islets.
backgroundThe aim of the present study was to investigate if an increased islet blood flow was associated with an enhanced total number of perfused islets, or whether only a subgroup of the islets increased their blood flow.
methodsFor this purpose, the whole pancreatic and islet blood flow was measured with a microsphere technique (4.5 x 10(5) microspheres/kg body wt) in anesthetized Sprague-Dawley rats. Blood flow measurements were made 3 min after an i.v. injection of 1 mL of saline, alloxan (75 mg/kg body wt), or D-glucose (300 mg/mL).
resultsAlloxan reduced whole pancreatic blood flow by 50%, but almost doubled islet blood flow. Glucose did not affect whole pancreatic blood flow, but increased islet blood flow 100%. Approximately 10% of the islets in control and glucose-injected rats contained microspheres, compared with about 25% in alloxan-injected rats (P < 0.001). When the islets containing a certain number of microspheres were compared, alloxan induced a homogeneous shift of the curve to the right, i.e., increased the number of islets that contained all amounts of microspheres. Glucose preferentially increased only the fraction of islets containing > or = 3 microspheres.
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