ArticleGlycoconjugate journal1996
Binding specificity of influenza C-virus to variably O-acetylated glycoconjugates and its use for histochemical detection of N-acetyl-9-O-acetylneuraminic acid in mammalian tissues.
Article in Glycoconjugate journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- 9-O Acetylated Gangliosides in Health and Disease.Biomolecules · 2023Review
- Tissue Microarrays to Visualize Influenza D Attachment to Host Receptors in the Respiratory Tract of Farm Animals.Viruses · 2021Article
- Review
- Exploration of the Sialic Acid World.Advances in carbohydrate chemistry and biochemistry · 2018Review
- Functions and Biosynthesis of O-Acetylated Sialic Acids.Topics in current chemistry · 2015Review
- The in situ distribution of glycoprotein-bound 4-O-Acetylated sialic acids in vertebrates.Glycoconjugate journal · 2014Article
- Lectins for histochemical demonstration of glycans.Histochemistry and cell biology · 2011Review
- O-Acetylated sialic acids and their role in immune defense.Advances in experimental medicine and biology · 2011Article
- Unique disialosyl gangliosides from salmon kidney: characterization of V3alphaFuc, IV3betaGalNAc, II3(alphaNeuAc)2-Gg4Cer and its analogue with 4-O-acetyl-N-acetylneuraminic acid.Glycoconjugate journal · 2006Article
- Identification of 9-O-acetyl-N-acetylneuraminic acid in normal canine pre-ocular tear film secreted mucins and its depletion in Keratoconjunctivitis sicca.Glycoconjugate journal · 2005Article
- Characterisation of the enzymatic 4-O-acetylation of sialic acids in microsomes from equine submandibular glands.Glycoconjugate journal · 2000Article
- Reduction of sialic acid O-acetylation in human colonic mucins in the adenoma-carcinoma sequence.Glycoconjugate journal · 1999Article
- The hemagglutinin-esterase of mouse hepatitis virus strain S is a sialate-4-O-acetylesterase.Journal of virology · 1999Article
- Sialic acids in molecular and cellular interactions.International review of cytology · 1997Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The specificity of influenza C-virus binding to sialoglycoconjugates was tested with various naturally O-acetylated gangliosides or synthetically O-acetylated sialic acid thioketosides, which revealed binding to 9-O-acetylated N-acetylneuraminic acid. Binding was also observed with a sample of Neu5,7Ac2-GD3, however at a lower degree. Sialic acids with two or three O-acetyl groups in the side chain of synthetic sialic acid derivatives are not recognized by the virus. In these experiments, bound viruses were detected with esterase substrates. Influenza C-virus was also used for the histological identification of mono-O-acetylated sialic acids in combination with an immunological visualization of the virus bound to thin-sections. The occurrence of these sialic acids was demonstrated in bovine submandibular gland, rat liver, human normal adult and fetal colon and diseased colon, as well as in human sweat gland. Submandibular gland and colon also contain significant amounts of glycoconjugates with two or three acetyl esters in the sialic acid side chain, demonstrating the value of the virus in discriminating between mono- and higher O-acetylation at the same site. The patterns of staining showed differences between healthy persons and patients with colon carcinoma, ulcerative colitis or Crohn's disease. Remarkably, some human colon samples did not show O-acetyl sialic acid-specific staining. The histochemical observations were controlled by chemical analysis of tissue sialic acids.
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