ReviewGlycoconjugate journal1996
Aglycone modulation of glycolipid receptor function.
Review in Glycoconjugate journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 82 citations in OpenAlex.
- Stereoconvergent and Chemoenzymatic Synthesis of Tumor-Associated Glycolipid Disialosyl Globopentaosylceramide for Probing the Binding Affinity of Siglec-7.ACS central science · 2024Article
- The Ying and Yang of Ganglioside Function in Cancer.Cancers · 2023Review
- Synthesis of a novel photoactivatable glucosylceramide cross-linker.Journal of lipid research · 2016Article
- Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure.Biophysical journal · 2014Article
- Leishmania mexicana infection induces IgG to parasite surface glycoinositol phospholipids that can induce IL-10 in mice and humans.PLoS neglected tropical diseases · 2013Article
- Structure-dependent pseudoreceptor intracellular traffic of adamantyl globotriaosyl ceramide mimics.The Journal of biological chemistry · 2012Article
- Biochemical, pathological and oncological relevance of Gb3Cer receptor.Medical oncology (Northwood, London, England) · 2011Article
- Glycosphingolipid functions.Cold Spring Harbor perspectives in biology · 2011Review
- Cholesterol modulates glycolipid conformation and receptor activity.Nature chemical biology · 2011Article
- A major fraction of glycosphingolipids in model and cellular cholesterol-containing membranes is undetectable by their binding proteins.The Journal of biological chemistry · 2010Article
- Review
- Polar lipid remodeling and increased sulfatide expression are associated with the glioma therapeutic candidates, wild type p53 elevation and the topoisomerase-1 inhibitor, irinotecan.Glycoconjugate journal · 2010Article
- Fatty acid-dependent globotriaosyl ceramide receptor function in detergent resistant model membranes.Journal of lipid research · 2009Article
- Uptake of the glycosphingolipid sulfatide in the gastrointestinal tract and pancreas in vivo and in isolated islets of Langerhans.Lipids in health and disease · 2006Article
- Structural characterization of the GM1 ganglioside by infrared multiphoton dissociation, electron capture dissociation, and electron detachment dissociation electrospray ionization FT-ICR MS/MS.Journal of the American Society for Mass Spectrometry · 2005Article
- Interaction of the verotoxin 1B subunit with soluble aminodeoxy analogues of globotriaosyl ceramides.The Biochemical journal · 2002Article
- Structure and function of a ganglioside receptor for porcine rotavirus.Journal of virology · 1998Article
- Expression and sulfogalactolipid binding specificity of the recombinant testis-specific cognate heat shock protein 70.Glycoconjugate journal · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aglycone has been largely ignored in consideration of glycoconjugate function. Evidence is reviewed which suggests that the role of the lipid in glycolipid carbohydrate function may be particularly significant. The lipid moiety can promote or reduce carbohydrate exposure of membrane glycolipids. Theoretical calculation has indicated that the plane of the plasma membrane can restrict the permitted conformations of a given glycolipid oligosaccharide. Thus the lipid moiety may influence the relative conformation of such carbohydrate sequences. Evidence of ceramide regulation of glycolipid function can be found in studies of enzyme substrate specificity, antiglycolipid recognition and bacterial/host cell interactions. Studies of verotoxin binding to its glycolipid receptor globotriaosyl ceramide indicate that modulation of receptor function by glycolipid fatty acid content plays an important role in in vitro binding assays, cell cytotoxicity and intracellular routing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.