ArticleThe Biochemical journal1996
An increase in cytosolic Ca2+ delays cAMP oscillations in Dictyostelium cells.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Characterizing the Role ofBiology · 2025Article
- Ion Signaling in Cell Motility and Development inBiomolecules · 2024Review
- Acidic Ca2+ stores, excitability, and cell patterning in Dictyostelium discoideum.Eukaryotic cell · 2009Review
- cAMP controls cytosolic Ca2+ levels in Dictyostelium discoideum.BMC cell biology · 2005Article
- A link of Ca2+ to cAMP oscillations in Dictyostelium: the calmodulin antagonist W-7 potentiates cAMP relay and transiently inhibits the acidic Ca2+-store.BMC developmental biology · 2004Article
- Fatty acids induce release of Ca2+ from acidosomal stores and activate capacitative Ca2+ entry in Dictyostelium discoideum.The Biochemical journal · 1998Article
- Mechanism of cAMP-induced Ca2+ influx in Dictyostelium: role of phospholipase A2.The Biochemical journal · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have shown that calmidazolium (R24571) causes a transient increase in the cytosolic free Ca2+ concentration ([Ca2+]i) in Dictyostelium discoideum [Schlatterer and Schaloske (1996) Biochem. J. 313, 661-667]. Here we have used R24571 to artifically increase [Ca2+]i during light-scattering oscillations and have found that, depending on the time of addition during the oscillatory cycle, R24571 suppressed cAMP synthesis and delayed the next spike for several minutes. Addition of Ca2+ to the medium, which also elevates [Ca2+]i, induced phase delays and resulted in a similar phase response curve as R24571. The magnitude of the phase delay was correlated with the point during the oscillatory cycle at which Ca2+ was added, indicating that an artificial increase in [Ca2+]i also resets the phase of the intrinsic oscillator.
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Registered trials
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