ArticleThe Biochemical journal1996
Tumour necrosis factor-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 126 citations in OpenAlex.
- Distinct mechanisms of type 3 secretion system recognition control LTB4 synthesis in neutrophils and macrophages.PLoS pathogens · 2024Article
- Distinct Mechanisms of Type 3 Secretion System Recognition Control LTBbioRxiv : the preprint server for biology · 2024Article
- RhoA/Rho Kinase Mediates Neuronal Death Through Regulating cPLAMolecular neurobiology · 2017Article
- Mito-xenophagic killing of bacteria is coordinated by a metabolic switch in dendritic cells.Scientific reports · 2017Article
- Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury.Neural regeneration research · 2017Review
- AS252424, a PI3Kγ inhibitor, downregulates inflammatory responsiveness in mouse bone marrow-derived mast cells.Inflammation · 2014Article
- The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-α signalling in cardiomyocytes.Cardiovascular research · 2014Article
- Dual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists.Cell death & disease · 2013Article
- TNF-α-induces airway hyperresponsiveness to cholinergic stimulation in guinea pig airways.British journal of pharmacology · 2012Article
- Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2008Article
- Mechanisms of neutrophil death in human immunodeficiency virus-infected patients: role of reactive oxygen species, caspases and map kinase pathways.Clinical and experimental immunology · 2007Article
- Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A2 in response to PMA.The Biochemical journal · 2005Article
- Differential phosphorylation of p38 induced by apoptotic and anti-apoptotic stimuli in murine hepatocytes.World journal of gastroenterology · 2005Article
- A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release.British journal of pharmacology · 2004Article
- Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes.The Biochemical journal · 2003Article
- Measurements of phospholipases A2, C, and D (PLA2, PLC, and PLD). In vitro microassays, analysis of enzyme isoforms, and intact-cell assays.Methods in molecular biology (Clifton, N.J.) · 2003Article
- Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.The Journal of experimental medicine · 2002Article
- Epstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4.Clinical and experimental immunology · 2001Article
- 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2.The Biochemical journal · 1999Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The role of the newly identified p38 mitogen-activated protein kinase (MAP kinase) in terminally differentiated cells, such as human neutrophils, is totally unknown. In order to examine the possible role of this MAP kinase in the phosphorylation and activation of cytoplasmic phospholipase A2 (cPLA2), we tested the effect of the recently synthesized inhibitor of p38 MAP kinase, SB 203580, on the phosphorylation and activation of both p38 MAP kinase and cPLA2. We found that while tumour necrosis factor-alpha (TNF-alpha)-stimulated tyrosine phosphorylation of p38 MAP kinase is affected only slightly by SB 203580, its stimulated kinase activity is greatly reduced in human neutrophils in suspension treated with this inhibitor. Furthermore, the TNF-alpha-stimulated phosphorylation and activation of cPLA2 are completely abolished in cells treated with SB 203580. Based on these data, it is reasonable to conclude that an SB 203580-sensitive kinase, or kinases and/or phosphatases, are involved in the phosphorylation and activation of cPLA2 in intact human neutrophils in suspension stimulated by TNF-alpha. The possible role of the p38 MAP kinase cascade in the phosphorylation and activation of cPLA2 is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.