Evidence map›Paper›PMID 8870500›Full record

ReviewTrends in biochemical sciences1996

The RNA polymerase II general elongation factors.

D Reines, J W Conaway, R C Conaway

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 134 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Structure of the transcribing RNA polymerase II-Elongin complex.Nature structural & molecular biology · 2023
    Article
  6. Article
  7. TCEA3 Attenuates Gastric Cancer Growth by Apoptosis Induction.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Article
  8. Article
  9. Review
  10. Genome-scale study of transcription factor expression in the branching mouse lung.Developmental dynamics : an official publication of the American Association of Anatomists · 2012
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. dELL is an essential RNA polymerase II elongation factor with a general role in development.Proceedings of the National Academy of Sciences of the United States of America · 2002
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

D ReinesDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
J W Conaway
R C Conaway
Emory University · US

Funding

BIOCHEMISTRY OF EUKARYOTIC MESSENGER RNA SYNTHESISR37GM041628 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI CONAWAY, RONALD C. · 2000 to 2009
$3.8M
RNA POLYMERASE II ELONGATION COMPLEX--STRUCTURE/FUNCTIONR01GM046331 · NIGMS · EMORY UNIVERSITY · PI REINES, DANIEL · 1991 to 2013
$3.5M
BIOCHEMISTRY OF EUKARYOTIC MESSENGER SYNTHESISR01GM041628 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI CONAWAY, JOAN W, CONAWAY, RONALD C. · 1989 to 2013
$1.5M
NIGMS NIH HHS GM41628NIGMS NIH HHS GM46331NIGMS NIH HHS R01 GM041628NIGMS NIH HHS R01 GM046331NIGMS NIH HHS R37 GM041628
6 · The paper itself

Abstract

Synthesis of eukaryotic messenger RNA by RNA polymerase II is governed by the concerted action of a set of general transcription factors that control the activity of polymerase during both the initiation and elongation stages of transcription. To date, five general elongation factors [P-TEFb, SII, TFIIF, Elongin (SIII) and ELL] have been defined biochemically. Here, we discuss these transcription factors and their roles in controlling the activity of the RNA polymerase II elongation complex.

Indexed as

Neoplasm ProteinsPeptide Elongation FactorsTranscriptional Elongation FactorsTranscription Factors, GeneralTranscription Factors, TFIIAnimalsDNA-Binding ProteinsElonginProtein BiosynthesisRNA Polymerase IITranscription FactorsTranscription, GeneticDNA-Binding ProteinsELL protein, humanElonginNeoplasm ProteinsPeptide Elongation FactorsRNA Polymerase IITranscriptional Elongation FactorsTranscription FactorsTranscription Factors, Generaltranscription factor S-IITranscription Factors, TFIItranscription factor TFIIF

Identifiers

PMID8870500
PMCPMC3374595
OpenAlexW2093800350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.