ArticleThe Journal of general physiology1996
Block of single L-type Ca2+ channels in skeletal muscle fibers by aminoglycoside antibiotics.
Article in The Journal of general physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Synergistic Cellular Responses Conferred by Concurrent Optical and Magnetic Stimulation Are Attenuated by Simultaneous Exposure to Streptomycin: An Antibiotic Dilemma.Bioengineering (Basel, Switzerland) · 2024Article
- Harmonizing Magnetic Mitohormetic Regenerative Strategies: Developmental Implications of a Calcium-Mitochondrial Axis Invoked by Magnetic Field Exposure.Bioengineering (Basel, Switzerland) · 2023Review
- GsMTx4-D provides protection to the D2.mdx mouse.Neuromuscular disorders : NMD · 2018Article
- Aminoglycoside antibiotics: structure, functions and effects on in vitro plant culture and genetic transformation protocols.Plant cell reports · 2010Review
- On the interaction of neomycin with the slow vacuolar channel of Arabidopsis thaliana.The Journal of general physiology · 2006Article
- Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2).Biophysical journal · 2004Article
- Voltage-dependent inhibition of rat skeletal muscle sodium channels by aminoglycoside antibiotics.Pflugers Archiv : European journal of physiology · 2004Article
- Adenophostin A and imipramine are two activators of the olfactory inositol 1,4,5-trisphosphate-gated channel in fish olfatory cilia.European biophysics journal : EBJ · 2003Article
- Ryanodine-induced structural alterations in the RyR channel suggested by neomycin block.Biophysical journal · 2002Article
- Block of the ryanodine receptor channel by neomycin is relieved at high holding potentials.Biophysical journal · 2002Article
- Gentamicin blocks ACh-evoked K+ current in guinea-pig outer hair cells by impairing Ca2+ entry at the cholinergic receptor.The Journal of physiology · 2000Article
- Streptomycin inhibition of myogenic tone, K+-induced force and block of L-type calcium current in rat cerebral arteries.The Journal of physiology · 1998Article
- Subconductance block of single mechanosensitive ion channels in skeletal muscle fibers by aminoglycoside antibiotics.The Journal of general physiology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activity of single L-type Ca2+ channels was recorded from cell-attached patches on acutely isolated skeletal muscle fibers from the mouse. The experiments were concerned with the mechanism by which aminoglycoside antibiotics inhibit ion flow through the channel. Aminoglycosides produced discrete fluctuations in the single-channel current when added to the external solution. The blocking kinetics could be described as a simple bimolecular reaction between an aminoglycoside molecule and the open channel. The blocking rate was found to be increased when either the membrane potential was made more negative or the concentration of external permeant ion was reduced. Both of these effects are consistent with a blocking site that is located within the channel pore. Other features of block, however, were incompatible with a simple pore blocking mechanism. Hyperpolarization enhanced the rate of unblocking, even though an aminoglycoside molecule must dissociate from its binding site in the channel toward the external solution against the membrane field. Raising the external permeant ion concentration also enhanced the rate of unblocking. This latter finding suggests that aminglycoside affinity is modified by repulsive interactions that arise when the pore is simultaneously occupied by a permeant ion and an aminoglycoside molecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.