ArticleThe Journal of physiology1996
ATP-activated cation conductance in a Xenopus renal epithelial cell line.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Purinergic signalling in the kidney in health and disease.Purinergic signalling · 2014Review
- Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells.Pflugers Archiv : European journal of physiology · 2004Article
- Extracellular adenine nucleotides regulate Na+/H+ exchanger NHE3 activity in A6-NHE3 transfectants by a cAMP/PKA-dependent mechanism.The Journal of membrane biology · 2002Article
- ATP stimulates Cl- secretion and reduces amiloride-sensitive Na+ absorption in M-1 mouse cortical collecting duct cells.The Journal of physiology · 2000Article
- Control of apical membrane chloride permeability in the renal A6 cell line by nucleotides.The Journal of physiology · 1999Article
- Extracellular ATP directly gates a cation-selective channel in rabbit airway ciliated epithelial cells.The Journal of physiology · 1998Article
- Calcium release from intracellular stores evoked by extracellular ATP in a Xenopus renal epithelial cell line.The Journal of physiology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Using a whole-cell voltage-clamp technique and fura-2 fluorescence measurements, the actions of extracellular adenosine 5'-triphosphate (ATP) in single cells of an epithelial cell line (A6), were investigated. 2. ATP (0.1-1000 microM) induced currents in cells held under voltage clamp. The sequence of purinergic agonist potency in activating the currents (2-methylthio ATP > adenosine 5'-diphosphate (ADP) > ATP > alpha, beta-methylene ATP) was consistent with that of P2y receptors. 3. Reversal potentials (Erev) of the currents under various ionic conditions suggest that potassium channels and non-selective cation channels were responsible for the ATP-activated conductance, which was permeable to calcium. 4. ATP activated the currents in a calcium-free extracellular solution. In the presence of extracellular calcium, the currents were completely inhibited with 10 mM EGTA in the pipette. 5. ATP (10 microM) increased the intracellular calcium concentration ([Ca2+]i) whether cells were bathed in a solution containing calcium or not. 6. These results indicate that ATP evoked a calcium-dependent cation conductance, permeable to calcium, through P2y receptors by releasing calcium from intracellular stores in A6 cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.