ArticleVirchows Archiv : an international journal of pathology1996
Expression of cyclin E in colorectal adenomas and adenocarcinomas: correlation with expression of Ki-67 antigen and p53 protein.
Article in Virchows Archiv : an international journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 63 citations in OpenAlex.
- Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A-dependent manner.Journal of cellular and molecular medicine · 2020Article
- Does cyclin E and p57International journal of clinical and experimental pathology · 2018Article
- MicroRNA-874-mediated inhibition of the major GThe Journal of biological chemistry · 2017Article
- Cyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies.BMC gastroenterology · 2014Article
- Expression of cyclin E in stage III colorectal carcinoma.Oncology letters · 2013Article
- Cell cyclins: triggering elements of cancer or not?World journal of surgical oncology · 2010Review
- Early carcinogenic events in HNPCC adenomas: differences with sporadic adenomas.Digestive diseases and sciences · 2008Article
- Cyclin E in normal and neoplastic cell cycles.Oncogene · 2005Review
- Inverse correlation between high level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder.Molecular pathology : MP · 2003Article
- Immunohistochemical expression of cyclin E in endometrial adenocarcinoma (endometrioid type) and its clinicopathological significance.Journal of cancer research and clinical oncology · 2003Article
- Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases.The American journal of pathology · 2000Article
- Nuclear Accumulation of B-Catenin in Human Endocrine Tumors: Association with Ki-67 (MIB-1) Proliferative Activity.Endocrine pathology · 2000Article
- Article
- In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions.Japanese journal of cancer research : Gann · 1998Article
- Prognostic significance of cyclin E and p53 protein overexpression in carcinoma of the renal pelvis and ureter.British journal of cancer · 1998Article
- Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas.Japanese journal of cancer research : Gann · 1997Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of cyclin E in human colorectal adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in the colorectal carcinogenesis. The expression of cyclin E was detected in 25% (91/358) of the adenomas and 56% (149/267) of the adenocarcinomas. The incidence of strongly positive cases was significantly higher in the adenocarcinomas (20%) than in the adenomas (5%) (P < 0.01). Among adenomas, a significant correlation was noticed between the expression of cyclin E and the grade of atypia. The incidence of cyclin E expression was significantly higher in the adenocarcinomas without an adenoma component (62%; 104/169) than in those with this component (46%; 45/98) (P < 0.05). Furthermore, the incidence of the cyclin E expression was higher in stages 1 and 2 carcinoma than in stage 0 and stages 3 and 4 carcinoma. The expression of cyclin E was the most prominent in tumors invading the submucosa and muscularis propria. The expression of cyclin E was significantly correlated with the proliferative activity of the tumor cells measured by Ki-67 antigen expression (P < 0.01). It was also correlated with the expression of p53 protein in the tumor cells (P < 0.01). Overexpression of cyclin E and subsequent deregulation of cell cycle may contribute to the development and early progression of the colorectal carcinomas.
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